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Antimutagenic Activity of Wheat Polypeptides in Human Cells Exposed to Cadmium Chloride

  • GENETICS
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Bulletin of Experimental Biology and Medicine Aims and scope

Antimutagenic effects of polypeptides isolated from Triticum kiharae wheat plantule extracts have been studied on human cells exposed to cadmium chloride. The most effective polypeptide Tk-AMP-BP β-purothionin exhibited higher antimutagenic activity than wheat water extract and another peptide isolated from the same wheat species, Tk-AMP-γ2 defensin; it also produced a pronounced antioxidant effect. This polypeptide can be used as a preventive agent for reducing the mutagenic potential of some environmental pollutants and for correction of human diseases associated with the defense system defects.

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Authors and Affiliations

  1. N. I. Vavilov Institute of General Genetics, the Russian Academy of Sciences, Moscow, Russia

    G. D. Zasukhina, I. M. Vasilyeva, I. A. Kadnikov, M. V. Voronin, T. I. Odintsova, T. V. Korostileva & V. A. Pukhalskii

Authors
  1. G. D. Zasukhina
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  2. I. M. Vasilyeva
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  3. I. A. Kadnikov
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  4. M. V. Voronin
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  5. T. I. Odintsova
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  6. T. V. Korostileva
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  7. V. A. Pukhalskii
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Corresponding author

Correspondence to G. D. Zasukhina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 155, No. 3, pp. 349–351, March, 2013

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Zasukhina, G.D., Vasilyeva, I.M., Kadnikov, I.A. et al. Antimutagenic Activity of Wheat Polypeptides in Human Cells Exposed to Cadmium Chloride. Bull Exp Biol Med 155, 370–372 (2013). https://doi.org/10.1007/s10517-013-2156-7

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  • DOI: https://doi.org/10.1007/s10517-013-2156-7

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