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Immunomodulating Effects of Vilon and Its Analogue in the Culture of Human and Animal Thymus Cells

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied molecular mechanisms of immunoprotective effects of two dipeptides, AB-O and R-1, on cultured human and rat thymic cells. Both dipeptides were shown to increase the expression of lymphocyte differentiation marker CD5 in thymic cells. Dipeptide АВ-0 induced T-cells precursor differentiation towards СD4+ T-helpers and its effect was weaker than that of dipeptide R-1. Dipeptide R-1 stimulates differentiation of CD5+ cells to mature T-helpers and cytotoxic СD8+ T cells and hence can be considered as a bioactive substance possessing immunomodulator and antiallergic activity.

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Authors and Affiliations

  1. I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    V. H. Khavinson

  2. St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia

    N. N. Sevostianova, N. S. Linkova, N. A. Chervyakova, A. V. Kostylev, R. I. Abdulragimov & V. H. Khavinson

  3. D. O. Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St. Petersburg, Russia

    V. O. Polyakova, A. O. Durnova & I. M. Kvetnoy

Authors
  1. N. N. Sevostianova
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  2. N. S. Linkova
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  3. V. O. Polyakova
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  4. N. A. Chervyakova
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  5. A. V. Kostylev
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  6. A. O. Durnova
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  7. I. M. Kvetnoy
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  8. R. I. Abdulragimov
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  9. V. H. Khavinson
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Corresponding author

Correspondence to N. S. Linkova.

Additional information

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 4, pp. 220–223, October, 2012

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Sevostianova, N.N., Linkova, N.S., Polyakova, V.O. et al. Immunomodulating Effects of Vilon and Its Analogue in the Culture of Human and Animal Thymus Cells. Bull Exp Biol Med 154, 562–565 (2013). https://doi.org/10.1007/s10517-013-2000-0

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  • DOI: https://doi.org/10.1007/s10517-013-2000-0

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