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Visualization of Experimental Glioma C6 by MRI with Magnetic Nanoparticles Conjugated with Monoclonal Antibodies to Vascular Endothelial Growth Factor

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Bulletin of Experimental Biology and Medicine Aims and scope

We developed a method for obtaining iron oxide nanoparticles and their conjugation with monoclonal antibodies to vascular endothelial growth factor. The resultant vector nanoparticles were low-toxic and the antibodies retained their immunochemical activity after conjugation. The study was carried out on rats with intracranial glioma C6 on day 14 after its implantation. The intravenously injected nanoparticles visualized the brain tumor in contrast to nanoparticles conjugated with nonspecific immunoglobulins that did not accumulate in the tumor.

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Authors and Affiliations

  1. Department of Medical Nanobiotechnologies, N. I. Pirogov Russian National Research Medical University, Moscow, Russia

    M. A. Abakumov, S. A. Shein, T. O. Sandalova, I. L. Gubskii & V. P. Chekhonin

  2. Faculty of Pharmacology, Center for Drug Delivery and Nanomedicine, Medical Center of the University of Nebraska, Omaha, USA

    H. Vishvasrao, M. Sokol’ski-Papkov, N. F. Grinenko & A. V. Kabanov

  3. Department of Basic and Applied Neurobiology; V. P. Serbskii Center of Social and Forensic Psychiatry, Ministry of Health Care and Social Development of the Russian Federation, Moscow, Russia

    N. V. Nukolova & V. P. Chekhonin

  4. Laboratory of Chemical Design of Bionanomaterials, Chemical Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia

    A. V. Kabanov

Authors
  1. M. A. Abakumov
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  2. S. A. Shein
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  3. H. Vishvasrao
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  4. N. V. Nukolova
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  5. M. Sokol’ski-Papkov
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  6. T. O. Sandalova
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  7. I. L. Gubskii
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  8. N. F. Grinenko
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  9. A. V. Kabanov
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  10. V. P. Chekhonin
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Corresponding author

Correspondence to M. A. Abakumov.

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Abakumov, M.A., Shein, S.A., Vishvasrao, H. et al. Visualization of Experimental Glioma C6 by MRI with Magnetic Nanoparticles Conjugated with Monoclonal Antibodies to Vascular Endothelial Growth Factor. Bull Exp Biol Med 154, 274–277 (2012). https://doi.org/10.1007/s10517-012-1929-8

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  • DOI: https://doi.org/10.1007/s10517-012-1929-8

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