We studied the effects of carbon monoxide and sodium hydrosulfide, hydrogen sulfide donor, on contractile activity of the left ventricle in Langendorf-perfused isolated rat heart. Carbon monoxide 5×10−5 M significantly accelerated sinus rhythm and left-ventricular pressure wave growth and decay. To the contrary, negative inotropic and chronotropic effects were observed at higher concentrations of carbon monoxide (10−4, 3×10−4 M). Sodium hydrosulfide (10−4-4×10−4 M) decreased all the parameters of left-ventricular contractive activity and reduced contraction rate. Carbon monoxide and hydrogen sulfide, which together with nitrogen oxide are qualified as a new class of gaseous signal compounds, may substantially modulate pumping function of the heart.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 153, No. 6, pp. 833-836, June, 2012
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Porokhya, M.V., Abramochkin, D.V., Abramov, A.A. et al. Inotropic Effects of Gaseous Transmitters in Isolated Rat Heart Preparation. Bull Exp Biol Med 153, 856–858 (2012). https://doi.org/10.1007/s10517-012-1843-0
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DOI: https://doi.org/10.1007/s10517-012-1843-0