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Changes in Activity of Proline-Specific Peptidases in Rat Model for Dementia of Alzheimer’s Type

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We studied the role of proline-specifi c peptidases in the pathogenesis of Alzheimer’s disease. Testing of conditioned passive avoidance 24 h after learning showed that chronic administration of scopolamine to rats 4-fold reduced the latency of entry into the dark chamber in comparison with controls (intact animals). Activity of prolyl endopeptidase was signifi cantly higher than in the controls in both the cortex and hippocampus. Changes in dipeptidyl peptidase IV activity were observed only in the cortex. Injection of AF-64A toxin into Meynert nucleus basalis reduced the latency of entry into the dark compartment by 75% in comparison with that in sham-operated and intact controls. Prolyl endopeptidase activity was reduced in the frontal cortex and hippocampus, but not in hypothalamus. Changes in dipeptidyl peptidase IV activity were detected only in the frontal cortex.

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References

  1. I. P. Ashmarin and S. V. Koroleva, Advanced Functional Neurochemistry, Eds. S. A. Dambinova and A. V. Arutjunian [in Russian], St. Petersburg (2003), pp. 85-94.

  2. N. N. Zolotov, O. A. Kutepova, T. A. Voronina, et al., Dokl. Akad. Nauk SSSR, 317, 234-237 (1991).

    PubMed  CAS  Google Scholar 

  3. A. Aguilar-Valles, E. Sánchez, P. de Gortari, et al., Neurochem. Int., 50, No. 2, 404-417 (2007).

    Article  PubMed  CAS  Google Scholar 

  4. S. L. Bernstein, N. F. Dupuis, N. D. Lazo, et al., Nat. Chem., 1, No. 4, 326-331 (2009).

    Article  PubMed  CAS  Google Scholar 

  5. L. Bertram, Int. Rev. Neurobiol., 84, 167-184 (2009).

    Article  PubMed  CAS  Google Scholar 

  6. M. M. Bradford, Anal. Biochem., 72, 248-254 (1976).

    Article  PubMed  CAS  Google Scholar 

  7. A. Fisher and I. Hanin, Ann. Rev. Pharmacol. Toxicol., 26, 161-181 (1986).

    Article  CAS  Google Scholar 

  8. F. Fonnum, J. Neurochem., 24, No. 2, 407-409 (1975).

    Article  PubMed  CAS  Google Scholar 

  9. A. J. Jalkanen, J. J. Hakkarainen, M. Lehtonen, et al., Basic. Clin. Pharmacol. Toxicol., 109, No. 6, 443-451 (2011).

    Article  PubMed  CAS  Google Scholar 

  10. P. T. Mannisto, P. Tuomainen, O. Kutepova, et al., Pharmacol. Biochem. Behav., 49, No. 1, 33-40 (1994).

    Article  PubMed  CAS  Google Scholar 

  11. R. Mentlein, Regul. Pept., 85, No. 1, 9-24 (1999).

    Article  PubMed  CAS  Google Scholar 

  12. L. Osherovich, Science Business Exchange, No. 1, 1-2 (2011).

  13. Y. S. Park, H. J. Jang, K. H. Lee, et al., J. Agric. Food Chem., 54, No. 4, 1238-1242 (2006).

    Article  PubMed  CAS  Google Scholar 

  14. S. Rossner, I. Schulz, U. Zeitschel, et al., Neurochem. Res., 30, Nos. 6-7, 695-702 (2005).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia

    G. A. Nazarova

  2. V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia

    K. N. Kolyasnikova & N. N. Zolotov

Authors
  1. G. A. Nazarova
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  2. K. N. Kolyasnikova
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  3. N. N. Zolotov
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Correspondence to G. A. Nazarova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 153, No. 5, pp. 628-630, May, 2012

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Nazarova, G.A., Kolyasnikova, K.N. & Zolotov, N.N. Changes in Activity of Proline-Specific Peptidases in Rat Model for Dementia of Alzheimer’s Type. Bull Exp Biol Med 153, 674–676 (2012). https://doi.org/10.1007/s10517-012-1796-3

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  • DOI: https://doi.org/10.1007/s10517-012-1796-3

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