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Antidepressant Activity of Diterpene Alkaloids of Aconitum baicalense Turcz

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Bulletin of Experimental Biology and Medicine Aims and scope

Course treatment with diterpene alkaloids of Aconitum baicalense in mice reduced the time of immobilization in the tail suspension test and produced an antiexudative effect in mouse model of serotonin-induced edema. In the open fi eld test, application of alkaloids did not change the total motor activity, orientation and exploratory behavior, and emotional reactions of animals. Experimental data suggest that diterpene alkaloids of Aconitum baicalensis exhibit antidepressant properties, possibly due to modulation of sensitivity to serotonin.

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Authors and Affiliations

  1. Laboratory of Phytopharmacology, Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia

    Yu. V. Nesterova, T. N. Povetieva & N. I. Suslov

  2. Solivey Company, Tomsk, Russia

    A. A. Semenov

  3. Tomsk Military Medical Institute, Tomsk, Russia

    S. V. Pushkarskiy

Authors
  1. Yu. V. Nesterova
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  2. T. N. Povetieva
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  3. N. I. Suslov
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  4. A. A. Semenov
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  5. S. V. Pushkarskiy
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Corresponding author

Correspondence to Yu. V. Nesterova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 151, No. 4, pp. 406–409, April, 2011

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Nesterova, Y.V., Povetieva, T.N., Suslov, N.I. et al. Antidepressant Activity of Diterpene Alkaloids of Aconitum baicalense Turcz . Bull Exp Biol Med 151, 425–428 (2011). https://doi.org/10.1007/s10517-011-1347-3

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  • DOI: https://doi.org/10.1007/s10517-011-1347-3

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