The hemopoiesis-stimulating effect of combined treatment with immobilized oligonucleotides and hyaluronidase preparations was studied during cytostatic-induced myelosuppression caused by cyclophosphamide administration. Immobilized hyaluronidase was shown to increase the effi ciency of correction of changes in the erythroid and granulocytic hemopoietic stems with immobilized oligonucleotides. This potentiation of the effect of immobilized oligonucleotides by immobilized hyaluronidase was related to an increase in functional activity of committed hemopoietic precursors.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 150, No. 11, pp. 545–549, November, 2010
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Dygai, A.M., Skurikhin, E.G., Pershina, O.V. et al. Hemopoiesis-Stimulating Activity of Immobilized Oligonucleotides and Hyaluronidase during Cytostatic-Induced Myelosuppression. Bull Exp Biol Med 150, 614–618 (2011). https://doi.org/10.1007/s10517-011-1204-4
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DOI: https://doi.org/10.1007/s10517-011-1204-4