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Effect of Inhibitors of Inducible and Neuronal NO Synthases on the Development of Audiogenic Stress-Induced Damage in Krushinskii–Molodkina Rats

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Bulletin of Experimental Biology and Medicine Aims and scope

Experiments on the models of epileptiform seizure and hemorrhagic stroke (Krushinskii–Molodkina rats) showed that selective inhibitors of inducible and neuronal NO synthases (aminoguanidine and 7-nitroindazole) significantly decrease the mortality rate, reduce the severity of motor disorders, and prevent the development of intracranial hemorrhages under conditions of audiogenic stress.

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Correspondence to V. P. Reutov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 150, No. 7, pp. 38–41, June, 2010

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Krushinskii, A.L., Kuzenkov, V.S., D’yakonova, V.E. et al. Effect of Inhibitors of Inducible and Neuronal NO Synthases on the Development of Audiogenic Stress-Induced Damage in Krushinskii–Molodkina Rats. Bull Exp Biol Med 150, 32–35 (2010). https://doi.org/10.1007/s10517-010-1060-7

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  • DOI: https://doi.org/10.1007/s10517-010-1060-7

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