Experiments on the models of epileptiform seizure and hemorrhagic stroke (Krushinskii–Molodkina rats) showed that selective inhibitors of inducible and neuronal NO synthases (aminoguanidine and 7-nitroindazole) significantly decrease the mortality rate, reduce the severity of motor disorders, and prevent the development of intracranial hemorrhages under conditions of audiogenic stress.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 150, No. 7, pp. 38–41, June, 2010
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Krushinskii, A.L., Kuzenkov, V.S., D’yakonova, V.E. et al. Effect of Inhibitors of Inducible and Neuronal NO Synthases on the Development of Audiogenic Stress-Induced Damage in Krushinskii–Molodkina Rats. Bull Exp Biol Med 150, 32–35 (2010). https://doi.org/10.1007/s10517-010-1060-7
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DOI: https://doi.org/10.1007/s10517-010-1060-7