The content of mRNA for α-synuclein (a key protein of the dopaminergic system) was elevated in the peripheral lymphocytes of patients with alcohol dependence syndrome. Increased level of α-synuclein mRNA was not associated with changes in the expression of NR4A2 gene encoding Nurrl, one of the main transcription factors of dopaminergic neurons.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 146, No. 11, pp. 545–547, November, 2008
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Taraskina, A.E., Filimonov, V.A., Kozlovskaya, Y.A. et al. High Level of α-Synuclein mRNA in Peripheral Lymphocytes of Patients with Alcohol Dependence Syndrome. Bull Exp Biol Med 146, 609–611 (2008). https://doi.org/10.1007/s10517-009-0345-1
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DOI: https://doi.org/10.1007/s10517-009-0345-1