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Study of in vivo biocompatibility and dynamics of replacement of rat shin defect with porous granulated bioceramic materials

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Biocompatibility of porous granulated bioceramic materials (hydroxyapatite, β-tricalcium phosphate, hydroxyapatite-β-tricalcium phosphate complex (80:20 wt%), carbonate-containing hydroxyapatite, and silicon-containing hydroxyapatite) was shown in a subcutaneous test on BDF1 mice. Dynamic (up to 8 months) observation showed gradual replacement of the granular substance with de novo forming bone tissue with hemopoiesis foci on a model of fenestral defect in the shin bone in Wistar rats. By the rate of resorption, the materials rank as follows: silicon-containing hydroxyapatite<hydroxyapatite<hydroxyapatite-β-tricalcium phosphate<β-tricalcium phosphate<carbonate-containing hydroxyapatite. The rate of resorption in bone tissue defect was significantly higher than in the subcutaneous test, but lagged behind (even for tricalcium phosphate and carbonate-containing hydroxyapatite) bone tissue formation de novo.

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Authors and Affiliations

  1. P. A. Hertzen Moscow Oncological Institute, Rosmedtechnologies, Moscow, Russia

    V. I. Chissov, I. K. Sviridova, N. S. Sergeeva, G. A. Frank, V. A. Kirsanova, S. A. Achmedova, I. V. Reshetov & M. M. Filjushin

  2. Institute of Physico-Chemical Problems of Ceramic Materials, Russian Academy of Sciences, Moscow, Russia

    S. M. Barinov, I. V. Fadeeva & V. S. Komlev

Authors
  1. V. I. Chissov
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  2. I. K. Sviridova
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  3. N. S. Sergeeva
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  4. G. A. Frank
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  5. V. A. Kirsanova
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  6. S. A. Achmedova
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  7. I. V. Reshetov
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  8. M. M. Filjushin
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  9. S. M. Barinov
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  10. I. V. Fadeeva
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  11. V. S. Komlev
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Corresponding author

Correspondence to N. S. Sergeeva.

Additional information

Translated from Kletochnye Tehnologii v Biologii i Medicine, No. 3, pp. 151–156, August, 2008

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Chissov, V.I., Sviridova, I.K., Sergeeva, N.S. et al. Study of in vivo biocompatibility and dynamics of replacement of rat shin defect with porous granulated bioceramic materials. Bull Exp Biol Med 146, 139–143 (2008). https://doi.org/10.1007/s10517-008-0222-3

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  • DOI: https://doi.org/10.1007/s10517-008-0222-3

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