Abstract
Single intravenous injection of paclitaxel to rats in a maximum tolerated dose of 4.6 mg/kg was accompanied by permanent structural and functional changes in the liver. The observed changes were typical of nonspecific reactive hepatitis: infiltration with lymphocytes and macrophages, pyknosis, and focal fatty degeneration of hepatocytes. Liver enzyme activity increased in blood plasma.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 145, No. 2, pp. 225–228, February, 2008
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Ermolaeva, L.A., Dubskaya, T.Y., Fomina, T.I. et al. Toxic effect of an antitumor drug paclitaxel on morphofunctional characteristics of the liver in rats. Bull Exp Biol Med 145, 263–265 (2008). https://doi.org/10.1007/s10517-008-0066-x
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DOI: https://doi.org/10.1007/s10517-008-0066-x