Skip to main content

Advertisement

SpringerLink
Log in

Ex vivo production of interferon-γ, tumor necrosis factor-α, and interleukin-6 by mouse macrophages during infection with M. bovis and M. tuberculosis H37Rv

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Ex vivo production of IFN-γ, TNF-α, and IL-6 by mouse peritoneal macrophages was studied during successive infection with the vaccine strain M. bovis BCG and virulent strain M. tuberculosis H37Rv. The increase in the concentrations of TNF-α and IL-6 did not depend on the sequence of macrophage infection with the vaccine or virulent strain, but was related to the presence of the vaccine strain M. bovis BCG in the medium. IFN-γ production depended on infection of macrophages with the virulent strain M. tuberculosis H37Rv. The concentration of IFN-γ was maximum during primary infection with the virulent strain and did not increase after successive infection with the virulent and vaccine strain.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. N. K. Zenkov, E. B. Men’shikova, N. N. Vol’skii, et al., Usp. Sovr. Biol., 117, No. 5, 439–449 (1999).

    Google Scholar 

  2. A. Pichugin and A. Anm, Probl. Tuberk., No. 12, 3–7 (2005).

  3. A. M. Cooper, L. B. Adams, D. K. Dalton, et al., Trends Microbiol., 10, No. 5, 221–226 (2002).

    Article  PubMed  CAS  Google Scholar 

  4. M. Engele, E. Stossel, K. Castiglione, et al., J. Immunol., 168, No. 3, 1328–1337 (2002).

    PubMed  CAS  Google Scholar 

  5. A. Molloy, P. Laochumroonvorapong, and G. Kaplan, J. Exp. Med., 180, No. 4, 1499–1509 (1994).

    Article  PubMed  CAS  Google Scholar 

  6. M. Oddo, T. Renno, A. Attinger, et al., J. Immunol., 160, No. 111, 5448–5454 (1998).

    PubMed  CAS  Google Scholar 

  7. F. Poveda, J. Camacho, F. Arnalich, et al., Infection, 27, Nos. 4–5, 272–274 (1999).

    Article  PubMed  CAS  Google Scholar 

  8. T. C. Tsao, J. Hong, C. Huang, et al., Tuber. Lung Dis., 79, No. 5, 279–285 (1999).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Central Research Institute of Tuberculosis of the Russian Academy of Medical Sciences, Moscow

    L. N. Chernousova & T. G. Smirnova

  2. V. A. Engel’gardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow

    E. G. Afanasieva, V. L. Karpov & A. V. Timofeev

Authors
  1. L. N. Chernousova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. G. Smirnova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. G. Afanasieva
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. L. Karpov
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. V. Timofeev
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. V. Timofeev.

Additional information

__________

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 11, pp. 552–555, November, 2007

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chernousova, L.N., Smirnova, T.G., Afanasieva, E.G. et al. Ex vivo production of interferon-γ, tumor necrosis factor-α, and interleukin-6 by mouse macrophages during infection with M. bovis and M. tuberculosis H37Rv. Bull Exp Biol Med 144, 709–712 (2007). https://doi.org/10.1007/s10517-007-0412-4

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-007-0412-4

Key Words

Search

Navigation