Skip to main content
SpringerLink
Log in

Effect of prostaglandins E2 and D2 on presynaptic NMDA receptors in rat cerebral cortex

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

We studied the effect of prostaglandins on presynaptic NMDA receptors. Prostaglandin E2 inhibited NMDA-induced 45Ca2+ uptake by synaptosomes in low concentrations (IC50 ∼10 µM), but potentiated it in higher concentrations. Prostaglandin D2 increased 45Ca2+ uptake by synaptosomes during stimulation of NMDA receptors. Our results indicate that prostaglandins D2 and E2 modulate function of presynaptic NMDA receptors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. L. N. Petrova and S. O. Bachurin, Byull. Eksp. Biol. Med., 142, No. 7, 51–54 (2006).

    Google Scholar 

  2. A. S. Ahmad, M. Ahmad, A. J. de Brum-Fernandes, and S. Dore, Brain Res., 1066, No. 1–2, 71–77 (2005).

    Article  PubMed  CAS  Google Scholar 

  3. A. Akaike, S. Kaneko, Y. Tamura, et al., Ibid., 663, No. 2, 237–243 (1994).

    Article  PubMed  CAS  Google Scholar 

  4. P. Bezzi, G. Carmignoto, L. Pasti, et al., Nature, 391, 281–285 (1998).

    Article  PubMed  CAS  Google Scholar 

  5. C. Cazevieille, A. Muller, F. Meynier, et al., Neurochem. Int., 24, No. 4, 395–398 (1994).

    Article  PubMed  CAS  Google Scholar 

  6. F. Hajos, Brain Res., 93, No. 3, 485–489 (1975).

    Article  PubMed  CAS  Google Scholar 

  7. L. S. Lerea, N. G. Carlson, M. Simonato, et al., J. Neurosci., 17, No. 1, 117–124 (1997).

    PubMed  CAS  Google Scholar 

  8. T. Muratani, M. Nishizawa, S. Matsumura, et al., J. Neurochem., 86, No. 2, 374–382 (2003).

    Article  PubMed  CAS  Google Scholar 

  9. I. Nishihara, T. Minami, Y. Watanabe, et al., Neurosci. Lett., 196, No. 1–2, 57–70 (1995).

    Article  PubMed  CAS  Google Scholar 

  10. T. Takadera and T. Ohyashiki, Life Sci., 78, No. 16, 1878–1883 (2006).

    Article  PubMed  CAS  Google Scholar 

  11. M. E. Turnbach and A. Randich, Pain, 97, No. 1–2, 127–137 (2002).

    Article  PubMed  CAS  Google Scholar 

  12. T. Yagami, H. Nakazato, K. Ueda, et al., Brain Res., 959, No. 2, 328–335 (2003).

    Article  PubMed  CAS  Google Scholar 

  13. L. C. Yang, M. Marsala, T. L. Yaksh, Neuroscience, 75, No. 2, 453–461 (1996).

    Article  PubMed  CAS  Google Scholar 

  14. M. Zonta, A. Sebelin, S. Gobbo, et al., J. Physiol., 553, No. 2, 404–414 (2003).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory for Neurochemistry of Physiologically Active Substances, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka

    L. N. Petrova, A. V. Gabrelian, I. V. Serkov & S. O. Bachurin

Authors
  1. L. N. Petrova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. V. Gabrelian
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. I. V. Serkov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. O. Bachurin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to L. N. Petrova.

Additional information

__________

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 144, No. 9, pp. 271–273, September, 2007

Rights and permissions

Reprints and permissions

About this article

Cite this article

Petrova, L.N., Gabrelian, A.V., Serkov, I.V. et al. Effect of prostaglandins E2 and D2 on presynaptic NMDA receptors in rat cerebral cortex. Bull Exp Biol Med 144, 298–300 (2007). https://doi.org/10.1007/s10517-007-0315-4

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-007-0315-4

Key Words

Search

Navigation