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Experimental model of hemorrhagic stroke: Rabbit immunization with HL-60 promyelocytic cell differentiation factor

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Abstract

Rabbits immunized with synthetic HLDF differentiation factor developed hemorrhagic stroke with thrombosis of small cerebral vessels and destruction of vascular endotheliocytes. The severity of stroke correlated with serum level of antibodies to differentiation factor. The role of different sites of HLDF molecule in the induction of clinical signs of hemorrhagic stroke was studied.

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References

  1. S. M. Dranitsyna, I. A. Kostanyan, S. G. Andreeva, et al., Bioorgan. Khim., 26, No. 5, 340–351 (2000).

    CAS  Google Scholar 

  2. I. A. Kostanyan, M. V. Astapova, E. V. Navolotskaya, et al., Ibid., 26, No. 7, 505–511 (2000).

    Article  CAS  Google Scholar 

  3. I. A. Kostanyan, M. V. Astapova, E. V. Starovoitova, et al., Ibid., 21, No. 4, 243–248 (1995).

    CAS  Google Scholar 

  4. A. N. Murashev, Proceedings of Inter-Departmental Scientific Council on Experimental and Applied Physiology [in Russian], Vol. 10, Moscow (2001), pp. 330–331.

    Google Scholar 

  5. E. V. Smirnova, A. V. Garkovenko, T. V. Rakitina, et al., Bioorgan. Khim., 30, No. 2, 130–140 (2004).

    CAS  Google Scholar 

  6. V. V. Sherstnev, V. I. Skvortsova, M. A. Gruden’, et al., Zh. Nevrol. Psikhiatr., Supplement: Stroke, No. 12, 53–59 (2004).

  7. C. Fieschi, M. Rasura, A. Anzini, and M. Beccia, J. Neurol. Sci., 153, 159–171 (1998).

    Article  PubMed  CAS  Google Scholar 

  8. H. Fujiwara, Y. Umeda, and S. Yonekura, Leukemia, 9, No. 9, 1602–1603 (1995).

    PubMed  CAS  Google Scholar 

  9. E. Harlow and D. Lane, Antibodies: A Laboratory Manual, New York (1988).

  10. D. E. McBean and P. A. Kelly, Gen. Pharmac., 30, No. 4, 431–434 (1998).

    Article  CAS  Google Scholar 

  11. T. Miyoshi, T. Otsuki, K. Omine, et al., Rinsho Ketsueki, 43, No. 10, 954–969 (2002).

    PubMed  Google Scholar 

  12. A. Ottani, S. Saltini, M. Bartiromo, et al., Brain Res., 986, Nos. 1–2, 181–190 (2003).

    Article  PubMed  CAS  Google Scholar 

  13. P. Seo and J. H. Stone, Am. J. Med., 11, 739–750 (2004).

    Google Scholar 

  14. R. D. Sewell, M. A. Gruden, D. M. Pache, et al., J. Psychopharmacol., 19, No. 6, 602–608 (2005).

    Article  PubMed  CAS  Google Scholar 

  15. C. G. Zimmerman-Ivol, P. R. Burkhard, J. Le Floch-Rohr, et al., Mol. Cell. Proteomics., 3, No. 1, 66–72 (2004).

    Article  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Hormonal Regulation Proteins, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Organic Biochemistry, Russian Academy of Sciences, Russia

    M. V. Gapon, S. M. Dranitsyna, N. I. Minkevich & I. A. Kostanyan

  2. Laboratory of Neurochemistry, P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Russia

    M. A. Gruden’

  3. Department of Pathological Anatomy, Medical Faculty of Russian University of Peoples’ Friendship, Russia

    I. I. Babichenko

Authors
  1. M. V. Gapon
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  2. S. M. Dranitsyna
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  3. N. I. Minkevich
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  4. M. A. Gruden’
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  5. I. I. Babichenko
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  6. I. A. Kostanyan
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 2, pp. 237–240, February, 2006

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Gapon, M.V., Dranitsyna, S.M., Minkevich, N.I. et al. Experimental model of hemorrhagic stroke: Rabbit immunization with HL-60 promyelocytic cell differentiation factor. Bull Exp Biol Med 141, 272–274 (2006). https://doi.org/10.1007/s10517-006-0147-7

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  • DOI: https://doi.org/10.1007/s10517-006-0147-7

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