Abstract
We studied molecular mechanisms of changes in oxidative metabolism under conditions of experimental lipopolysaccharide-induced endotoxemia. Generation of reactive nitrogen and oxygen species in mice increased 18 h after treatment with lipopolysaccharide. These changes contributed to inactivation of enzymes and enzyme complexes (ribonucleotide reductase, NADH-ubiquinone oxidoreductase, and cytochrome c oxidase), dysfunction of the mitochondrial electron transport chain, and development of oxidative stress. Plaferon LB protected mice from the toxic effect of lipopolysaccharide.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 2, pp. 172–176, February, 2006
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Sanikidze, T.V., Tkhilava, N.G., Papava, M.B. et al. Role of free nitrogen and oxygen radicals in the pathogenesis of lipopolysaccharide-induced endotoxemia. Bull Exp Biol Med 141, 211–215 (2006). https://doi.org/10.1007/s10517-006-0130-3
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DOI: https://doi.org/10.1007/s10517-006-0130-3