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Stress reactions in rats during immunization to serotonin

  • Physiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

We studied the effect of immunization with a serotonin-bovine serum albumin conjugate on parameters of stress reaction to immobilization stress in rats. Active immunization was accompanied by changes in parameters reflecting animal resistance to emotional stress. The observed changes can be interpreted as a decrease in individual resistance to emotional stress. Active immunization of rats with a serotonin-bovine serum albumin conjugate was accompanied by production of autoantibodies against serotonin and dopamine. The role of autoantibodies against dopamine in modulation of the effect of immunization with serotonin-bovine serum albumin conjugate on the stress reaction in rats is discussed.

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References

  1. L. A. Basharova, L. A. Vetrile, N. A. Bobkova, et al., Patol. Fiziol. Eksp. Ter., No. 1, 41–43 (1993).

  2. E. A. Gromova, T. P. Semenova, A. R. Chubakov, and N. B. Bobkova, Reciprocal Relations between Serotoninergic and Noradrenergic Systems of the Brain and their Role in the Regulation of Behavior under Normal and Pathological Conditions [in Russian], Pushchino (1985).

  3. T. V. Davydova, V. G. Fomina, L. A. Vetrile, et al., Byull. Eksp. Biol. Med., 137, No. 6, 610–613 (2004).

    Google Scholar 

  4. L. V. Devoino and E. L. Al’perina, Fiziol. Zh., No. 2, 239–246 (1984).

  5. V. A. Evseev, T. V. Davydova, V. G. Fomina, et al., Byull. Eksp. Biol. Med., 116, No. 12, 582–584 (1993).

    CAS  Google Scholar 

  6. V. G. Zilov, Brain. Theoretical and Clinical Aspects [in Russian], Moscow (2003), pp. 68–84.

  7. K. V. Sudakov, Individual Resistance to Emotional Stress [in Russian], Moscow (1998).

  8. K. Pacak and M. Palkovits, Endocr. Rev., 22, 502–548 (2001).

    Article  CAS  PubMed  Google Scholar 

  9. A. E. Umriukhin, A. Wigger, N. Singewald, and R. Landgraf, Stress, 5, 299–305 (2002).

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Russia

    A. E. Umriukhin, A. N. Kravtsov & K. V. Sudakov

  2. Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow

    L. A. Vetrile, N. A. Trekova & V. A. Evseev

Authors
  1. A. E. Umriukhin
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  2. A. N. Kravtsov
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  3. L. A. Vetrile
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  4. N. A. Trekova
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  5. V. A. Evseev
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  6. K. V. Sudakov
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Corresponding author

Correspondence to A. E. Umriukhin.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 140, No. 12, pp. 604–607, December, 2005

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Umriukhin, A.E., Kravtsov, A.N., Vetrile, L.A. et al. Stress reactions in rats during immunization to serotonin. Bull Exp Biol Med 140, 655–657 (2005). https://doi.org/10.1007/s10517-006-0046-y

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  • DOI: https://doi.org/10.1007/s10517-006-0046-y

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