Abstract
Suppression of the cell component of the immune system and open-field behavior developing in OXYS rats by the age of 3 months are regarded as manifestations of accelerated aging. Stimulation of cell-mediated immune response with BCG vaccine caused a dose-dependent increase of orientation and exploratory activity of OXYS rats in the open field test to virtually the same level as in Wistar rats.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
N. D. Beklemishev and G. S. Sukhodoeva, Allergy to Bacteria: Clinical and Experimental Study [in Russian], Moscow (1979).
J. Bures, O. Buresova, and D. P. Houston, Methods and Main Experiments for Studies of the Brain and Behavior [in Russian], Moscow (1991).
N. G. Kolosova, P. A. Lebedev, S. V. Aidagulova, and T. S. Morozkova, Byull. Eksp. Biol Med., 133, No.10, 235–240 (2003).
N. G. Kolosova, T. V. Shcheglova, T. G. Amstislavskaya, and L. V. Loskutova, Ibid., 135, No.6, 696–699 (2003).
L. V. Loskutova and L. M. Zelenkina, Zh. Vyssh. Nervn. Deyat., 52, No.3, 366–371 (2002).
L. V. Loskutova and N. G. Kolosova, Byull. Eksp. Biol Med., 130, No.8, 155–158 (2000).
E. V. Markova, N. A. Korotkova, I. A. Gol'dina, et al., Ibid., 132, No.10, 424–426 (2001).
E. V. Markova, L. A. Obukhova, and N. G. Kolosova, Ibid., 136, No.10, 427–429 (2003).
E. V. Markova, T. G. Chernova, P. N. Fillimonov, et al., Ibid., 138, No.10, 466–469 (2004).
K. J. Erb, J. Kirmann, B. Delahant, et al., Eur. Cytokine Netw., 10, No.2, 147–153 (1999).
I. E. Flesch, J. H. Hess, S. Huang, et al., J. Exp. Med., 181, 1615 (1995).
J. L. Flynn, J. Chan, K. J. Triebold, et al., Ibid., 178, 2249–2254 (1993).
C. S. Hsieh, S. E. Macatonia, C. S. Tripp, et al., Science, 260, 547 (1993).
E. V. Markova, N. Y. Gromykhina, V. V. Abramov, and V. A. Kozlov, Russ. J. Immunol., 5, No.1, 89–95 (2000).
C. Todorovic, M. Dimitrijevic, S. Stanojevic, et al., Int. J. Neurosci., 113, No.9, 1259–1273 (2003).
Author information
Authors and Affiliations
Corresponding author
Additional information
__________
Translated from Byulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 140, No. 9, pp. 332–334, September, 2005
Rights and permissions
About this article
Cite this article
Markova, E.V., Kozlov, V.A., Trofimova, N.A. et al. Stimulation of Cell Component of the Immune Response Activates Exploratory Behavior in Senescence Accelerated OXYS Rats. Bull Exp Biol Med 140, 345–347 (2005). https://doi.org/10.1007/s10517-005-0486-9
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10517-005-0486-9