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High stability voltage controlled current source for cervical cancer detection using electrical impedance spectroscopy

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Abstract

The design of a high stability voltage controlled current source (VCCS) for cervical cancer detection (CCD) applying electrical bio-impedance spectroscopy (EBS) is presented. The circuit was designed, simulated and fabricated in TSMC 130 nm CMOS technology at 1.3 V power supply. The proposed Howland current source is based on self-biased complementary folded cascode (SB-CFC) operational amplifier (OA). Complying with the requirements for medical electrical equipment of international standard ABNT-NBR-IEC-60601-1 the sinusoidal current peak amplitude was settled at 10 μA. In accordance with the requirements of the EBS for CCD, the specifications for the SB-CFC-OA were calculated to meet the 100 Hz–1 MHz frequency range for the sinusoidal output current and the output impedance higher than 1 MΩ at 1 MHz frequency. Post-layout simulations were run and the main results were: 10 ± 0.0335 μA for the output current peak amplitude over the specified frequency range and with 5 kΩ load impedance; values above 1.6 MΩ output impedance at 1 MHz; nominal current amplitude variations lower than 0.4 % for load impedances in the range of 10 Ω up to 5 kΩ. And the experimental result for maximum non-linearity was 2.19 % of full scale. From these results, the performance of the VCCS is adequate for EBS-CCD applications.

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Acknowledgments

The authors wish thank CNPq—Brazilian National Council of Scientific and Technological Development for support and collaboration.

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Authors and Affiliations

  1. Universidade de São Paulo, São Paulo, SP, Brazil

    José Alejandro Amaya Palacio & Wilhelmus Adrianus Van Noije

  2. Universidad Industrial de Santander, Bucaramanga, Santander, Colombia

    José Alejandro Amaya Palacio

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  1. José Alejandro Amaya Palacio
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  2. Wilhelmus Adrianus Van Noije
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Correspondence to José Alejandro Amaya Palacio.

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Amaya Palacio, J.A., Van Noije, W.A. High stability voltage controlled current source for cervical cancer detection using electrical impedance spectroscopy. Analog Integr Circ Sig Process 89, 541–547 (2016). https://doi.org/10.1007/s10470-016-0828-8

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  • DOI: https://doi.org/10.1007/s10470-016-0828-8

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