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The Association Between Objectively-Measured Physical Activity and Cognitive Functioning in Middle-Aged and Older People Living with HIV

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Abstract

Middle-aged and older people living with HIV (PWH) are at higher risk for cognitive impairment and engage in lower levels of physical activity (PA) than seronegative counterparts. Research examining the association between objectively-measured PA and cognitive function in this population is scarce. This cross-sectional study examined the association between accelerometry-measured PA and cognitive functioning among 75 PWH (mean age 55.63). Light PA was the PA variable with the most consistent associations with cognition, with more minutes per week of light PA (performed in bouts of ≥ 10 min) being associated with better executive function, working memory/attention, and speed of processing performance, adjusted for age and current CD4 count. Findings suggest that although middle-aged and older PWH engage in more light than moderate-to-vigorous PA, light PA may be beneficial to cognition. Longitudinal studies are needed to understand PA dose–response associations with cognitive trajectories, cognitive domain specificity of PA effects, and underlying neural mechanisms of PA.

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De-identified data may be provided in justified circumstances to qualified individuals.

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Funding

This study was supported by National Institutes of Health (NIH) Grants R24-AI067039 [CFAR Network of Integrated Clinical Systems (CNICS)], R01-NR018391 (PROSPER-HIV) and 3R01-NR018391-02S2 (PROSPER-HIV ADRD Supplement).

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Authors and Affiliations

  1. School of Nursing, University of Alabama at Birmingham, Birmingham, USA

    Pariya L. Fazeli & David E. Vance

  2. School of Medicine, University of Alabama at Birmingham, Birmingham, USA

    Amanda L. Willig, Thomas W. Buford & Greer Burkholder

  3. School of Nursing, University of Washington, Seattle, USA

    Vitor Oliveira & Allison R. Webel

  4. Department of Medicine, University of Washington, Seattle, USA

    Heidi M. Crane

  5. Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, USA

    Christine Horvat Davey

  6. Fenway Health, Boston, USA

    Julia Fleming

  7. Department of Family, Community, and Health Systems, UAB School of Nursing, NB 470C, 1720 2nd Avenue South, Birmingham, AL, 35294-1210, USA

    Pariya L. Fazeli

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  1. Pariya L. Fazeli
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  3. Vitor Oliveira
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Per ICMJE guidelines, all authors whose names appear on the submission: (1) made substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data; (2) drafted the work or revised it critically for important intellectual content; (3) approved the version to be published; and (4) agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

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Correspondence to Pariya L. Fazeli.

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Fazeli, P.L., Willig, A.L., Oliveira, V. et al. The Association Between Objectively-Measured Physical Activity and Cognitive Functioning in Middle-Aged and Older People Living with HIV. AIDS Behav 27, 1199–1210 (2023). https://doi.org/10.1007/s10461-022-03857-5

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