Abstract
High mechanical stress in atherosclerotic plaques at vulnerable sites, called critical stress, contributes to plaque rupture. The site of minimum fibrous cap (FC) thickness (FCMIN) and plaque shoulder are well-documented vulnerable sites. The inherent weakness of the FC material at the thinnest point increases the stress, making it vulnerable, and it is the big curvature of the lumen contour over FC which may result in increased plaque stress. We aimed to assess critical stresses at FCMIN and the maximum lumen curvature over FC (LCMAX) and quantify the difference to see which vulnerable site had the highest critical stress and was, therefore, at highest risk of rupture. One hundred patients underwent high resolution carotid magnetic resonance (MR) imaging. We used 352 MR slices with delineated atherosclerotic components for the simulation study. Stresses at all the integral nodes along the lumen surface were calculated using the finite-element method. FCMIN and LCMAX were identified, and critical stresses at these sites were assessed and compared. Critical stress at FCMIN was significantly lower than that at LCMAX (median: 121.55 kPa; inter quartile range (IQR) = [60.70–180.32] kPa vs. 150.80 kPa; IQR = [91.39–235.75] kPa, p < 0.0001). If critical stress at FCMIN was only used, then the stress condition of 238 of 352 MR slices would be underestimated, while if the critical stress at LCMAX only was used, then 112 out of 352 would be underestimated. Stress analysis at FCMIN and LCMAX should be used for a refined mechanical risk assessment of atherosclerotic plaques, since material failure at either site may result in rupture.
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Acknowledgments
This research is partly supported by ARTreat FP7 Europain Union and NIHR Cambridge Biomedical Research Centre. Dr. Umar Sadat is funded by the Medical Research Council & Royal College of Surgeons of England Joint Clinical Research Training Fellowship. We thank Tim Baynes from University of Cambridge for proof reading of this manuscript.
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Associate Editor Jane Grande-Allen oversaw the review of this article.
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Teng, Z., Sadat, U., Li, Z. et al. Arterial Luminal Curvature and Fibrous-Cap Thickness Affect Critical Stress Conditions Within Atherosclerotic Plaque: An In Vivo MRI-Based 2D Finite-Element Study. Ann Biomed Eng 38, 3096–3101 (2010). https://doi.org/10.1007/s10439-010-0078-3
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DOI: https://doi.org/10.1007/s10439-010-0078-3