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Hemodynamic Computation Using Multiphase Flow Dynamics in a Right Coronary Artery

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Abstract

Hemodynamic data on the roles of physiologically critical blood particulates are needed to better understand cardiovascular diseases. The blood flow patterns and particulate buildup were numerically simulated using the multiphase non-Newtonian theory of dense suspension hemodynamics in a realistic right coronary artery (RCA) having various cross sections. The local hemodynamic factors, such as wall shear stress (WSS), red blood cell (RBC) buildup, viscosity, and velocity, varied with the spatially nonuniform vessel structures and temporal cardiac cycles. The model generally predicted higher RBC buildup on the inside radius of curvature. A low WSS region was found in the high RBC buildup region, in particular, on the area of maximum curvature of a realistic human RCA. The complex recirculation patterns, the oscillatory flow with flow reversal, and vessel geometry resulted in RBC buildup due to the prolonged particulate residence time, specifically, at the end of the diastole cycle. The increase of the initial plasma viscosity caused the lower WSS. These predictions have significant implications for understanding the local hemodynamic phenomena that may contribute to the earliest stage of atherosclerosis, as clinically observed on the inside curvatures and torsion of coronary arteries.

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ACKNOWLEDGMENTS

We thank Dr Marc Horner of Fluent, Inc., for his technical support with the FLUENT code and Professor Sanjeev G. Shroff of the University of Pittsburgh and Dr Chandrakant B. Panchal of ANL for their advice in the biomedical area. This study was supported under U.S. Department of Energy contract W-31-109-Eng-38.

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  1. Argonne National Laboratory, 9700 S. Cass Avenue, Argonne, IL, USA

    Jonghwun Jung, Ahmed Hassanein & Robert W. Lyczkowski

  2. Argonne National Laboratory, Energy Technology Division, Building 308,9700 South Cass Avenue, Argonne, IL, 60439, USA

    Jonghwun Jung

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Jung, J., Hassanein, A. & Lyczkowski, R.W. Hemodynamic Computation Using Multiphase Flow Dynamics in a Right Coronary Artery. Ann Biomed Eng 34, 393–407 (2006). https://doi.org/10.1007/s10439-005-9017-0

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