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Preoperative diagnosis of a giant cell tumor of soft tissue arising from the breast by ultrasound-guided core needle biopsy

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Abstract

Giant cell tumors of soft tissue (GCT-ST) arising in the breast are extremely rare. Herein, we report a case of a 45-year-old woman with a 5-cm mass in her left breast. Ultrasonography revealed a mainly well-circumscribed mass that contained a cystic lesion. Magnetic resonance imaging showed a fibrous capsule-covered mass that contained a high-intensity area, suggesting hemorrhaging. Ultrasound-guided core needle biopsy (CNB) revealed mononuclear histiocytic cells with a round shape or spindled appearance that was mixed with multinucleated giant cells. Immunohistochemical analysis revealed CD68-positive staining in the mononuclear and giant cells but negative staining for pancytokeratin. Preoperatively, the tumor was highly suspected of being GCT-ST. Histopathological results after a left mastectomy showed similar findings to CNB. The final diagnosis was GCT-ST in the breast. To the best of our knowledge, this is the first case report of a GCT-ST arising in the breast diagnosed by ultrasound-guided CNB.

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Acknowledgements

The authors would like to thank Dr. Bryan J. Mathis of the Medical English Communication Center (University of Tsukuba, Japan) for native English editing of this manuscript.

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Authors and Affiliations

  1. Department of Breast-Thyroid-Endocrine Surgery, Tsukuba University Hospital, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan

    Aya Sawa & Tatsuhiko Ikeda

  2. Department of Breast and Endocrine Surgery, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan

    Tatsuhiko Ikeda, Emika Ichioka, Yukiko Tsushima, Akiko Iguchi-Manaka, Hiroko Bando & Hisato Hara

  3. Department of Diagnostic Pathology, Kasumigaura Medical Center, Ibaraki, Japan

    Yuzuru Kondo

Authors
  1. Aya Sawa
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  2. Tatsuhiko Ikeda
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  3. Emika Ichioka
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  4. Yukiko Tsushima
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  5. Akiko Iguchi-Manaka
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  6. Hiroko Bando
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  7. Yuzuru Kondo
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  8. Hisato Hara
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Corresponding author

Correspondence to Tatsuhiko Ikeda.

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Conflict of interest

Aya Sawa, Tatsuhiko Ikeda, Emika Ichioka, Yukiko Tsushima, Akiko Iguchi, Hiroko Bando, Yuzuru Kondo, and Hisato Hara declare that they have no conflicts of interest.

Ethical statement

All procedures followed were in accordance with the ethical standards of the responsible committees on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. Informed consent was obtained from all patients prior to inclusion in the study.

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Sawa, A., Ikeda, T., Ichioka, E. et al. Preoperative diagnosis of a giant cell tumor of soft tissue arising from the breast by ultrasound-guided core needle biopsy. J Med Ultrasonics 46, 257–261 (2019). https://doi.org/10.1007/s10396-018-0891-0

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  • DOI: https://doi.org/10.1007/s10396-018-0891-0

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