Abstract
Aim
To investigate the features of type-specific persistent HPV infection and the associated risk factors in Uyghur women.
Subjects and methods
From September 2012 to August 2013, Uyghur women who underwent opportunistic screening for cervical cancer at the People’s Hospital of Xinjiang Uygur Autonomous Region were recruited during the baseline investigation. After testing for HPV infection and genotyping, 300 women with chronic cervicitis and 300 women negative for HPV were enrolled in the nested case-control study. Information came from the sample subjects interviewed using questionnaires and follow-up study.
Results
The type-specific persistent HPV infection rate was 25.50 % (65/255). The top five most common HPV types were HPV16 (48.00 %), HPV18 (31.03 %), HPV58 (28.30 %), HPV52 (23.40 %) and HPV45 (21.43 %). The risk of type-specific persistent HPV infection was increased 4.81-fold for HPV16 compared with non-HPV16. Compared with transient HPV infection, menopause and not using condoms were risk factors for persistent infection.
Conclusion
The risk factors for persistent HPV infection for Uyghur women included having HPV16 infection, having menopause and not using condoms. Regular screening and close follow-up should be carried out in this high-risk population.
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Acknowledgments
This research was supported by grants from the research project of the People’s Hospital of Xinjiang Uygur Autonomous Region, “The study on the risk factors of high-risk HPV persistent infection in Uygur women” (20140203).
Authors’ contributions
MN, SS and LW conceived of the study, participated in its design and coordination and helped to collect data and do statistical analysis as well as draft the manuscript. KCZ, ZJ and PL participated in the collection of clinical and experimental data and performed the statistical analysis and drafting of the manuscript as well as the manuscript review and final calibration. All authors read and approved the final manuscript.
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Shuang Sui and Mayineur Niyazi1 are the co-first authors
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Sui, S., Niyazi, M., Wang, L. et al. A nested case-control study on type-specific persistent HPV infection in Uyghur women. J Public Health 24, 245–251 (2016). https://doi.org/10.1007/s10389-016-0720-0
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DOI: https://doi.org/10.1007/s10389-016-0720-0