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Late toxicity after definitive chemoradiotherapy for esophageal squamous cell carcinoma

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Abstract

Background

This study was designed to conduct a retrospective analysis of late toxicity following chemoradiotherapy (CRT) for esophageal carcinoma.

Methods

The 49 first-onset esophageal carcinoma cases who allowed evaluation of late toxicity were the subjects. The incidence, severity, and background factors were analyzed for late toxicity (pneumonitis, pleural effusion, pericardial effusion). Performance status (PS) was 0/1/2/3 in 8/32/7/2 cases, respectively. The tumor-occupied site was Ce/Ut/Mt/Lt in 10/15/12/12 cases, respectively. T was 1/2/3/4 in 6/7/14/22 cases, and cStage was I/II/III/IVa/IVb in 6/9/8/23/3 cases, respectively. The radiation dose was <60 Gy/≥60 Gy in 12/37 cases. Concomitant chemotherapy was absent/present in 7/42 cases. Logistic regression analysis was conducted.

Results

Pneumonitis was seen in 19 cases (39%), and its severity was grade 1/2/3 in 10/5/4 cases, respectively. Pleural effusion was noted in 15 cases (31%), and its severity was grade 1/2/3 in 9/5/1 cases, respectively. Pericardial effusion was seen in 10 cases (20%), and severity was grade 1/3 in 8/2 cases, respectively. In cases complicated by severe pneumonitis, a PS ≥ 2 was identified as an associated background factor. The tumor-occupied area (Mt/Lt) was identified as a background factor associated with severe pleural effusion. Age (≥75 years) was identified as a factor associated with pericardial effusion.

Conclusions

Particular care is needed for a possible severe course of pneumonitis in cases with a PS ≥ 2, the likelihood of severe pleural effusion in cases with Mt/Lt cancer, and the likelihood of pericardial effusion in elderly patients. Measures to reduce late toxicity following chemoradiotherapy for esophageal carcinoma are desirable.

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Authors and Affiliations

  1. Department of Surgery, Osaka General Medical Center, 3-1-56 Bandai-higashi, Sumiyoshi-ku, Osaka, 558-8558, Japan

    Kazuhiro Nishikawa, Kazuhiro Iwase, Toyokazu Aono, Masaya Nomura, Hiroshi Tamagawa, Chu Matsuda, Tsuyoshi Takahashi & Yasuhiro Tanaka

  2. Department of Radiation Oncology, Osaka General Medical Center, Osaka, Japan

    Shigetoshi Shimamoto

  3. Department of Surgery, National Hospital Organization Kure Medical Center/Chugoku Cancer Center, Kure, Japan

    Shunji Endo

Authors
  1. Kazuhiro Nishikawa
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  2. Kazuhiro Iwase
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  3. Toyokazu Aono
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  4. Masaya Nomura
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  5. Hiroshi Tamagawa
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  6. Chu Matsuda
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  7. Tsuyoshi Takahashi
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  8. Shigetoshi Shimamoto
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  9. Shunji Endo
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  10. Yasuhiro Tanaka
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Correspondence to Kazuhiro Nishikawa.

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Nishikawa, K., Iwase, K., Aono, T. et al. Late toxicity after definitive chemoradiotherapy for esophageal squamous cell carcinoma. Esophagus 7, 49–52 (2010). https://doi.org/10.1007/s10388-010-0224-x

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  • DOI: https://doi.org/10.1007/s10388-010-0224-x

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