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Prediction of severe retinopathy of prematurity using the weight gain, insulin-like growth factor 1, and neonatal retinopathy of prematurity algorithm in a Japanese population of preterm infants

  • Clinical Investigation
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Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To retrospectively investigate the sensitivity and specificity of weight gain, insulin-like growth factor 1, and neonatal retinopathy of prematurity (WINROP) algorithm for the prediction of severe retinopathy of prematurity (ROP) in a Japanese population of preterm infants. The WINROP algorithm is a tool based on postnatal weight gain.

Study design

Retrospective cohort study.

Methods

The medical records of preterm infants born between January 2011 and March 2017 were retrospectively reviewed. Infants born after 33 weeks of gestation were excluded based on the indications of the WINROP algorithm. Postnatal weight was recorded weekly on the WINROP system until postmenstrual week 36. The sensitivity and specificity of the WINROP algorithm were analyzed.

Results

In total, 278 infants were included in this study. Based on the WINROP algorithm 110 of these infants were predicted to be at low risk for developing severe ROP and 105 did not develop severe ROP. Based on the WINROP algorithm 168 infants were predicted to be at high risk for developing severe ROP　and 27 developed severe ROP. Thus, the sensitivity of the WINROP algorithm was 84.4% and the specificity 42.7%.

Conclusion

The WINROP algorithm could be used for preterm infants (gestational age of <28 weeks) without a complicated hospital course. Modification of the algorithm will improve its sensitivity and specificity for the Japanese population.

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Authors and Affiliations

  1. Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan

    Kaori Ueda, Akiko Miki, Shunichiro Nakai & Makoto Nakamura

  2. Department of Ophthalmology, Hyogo Prefectural Kobe Children’s Hospital, Kobe, Japan

    Suiho Yanagisawa & Koji Nomura

Authors
  1. Kaori Ueda
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  2. Akiko Miki
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  3. Shunichiro Nakai
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  4. Suiho Yanagisawa
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  5. Koji Nomura
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  6. Makoto Nakamura
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Correspondence to Akiko Miki.

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Conflicts of Interest

K. Ueda, None; A. Miki, None; S. Nakai, None; S. Yanagisawa, None; K. Nomura, None; M. Nakamura, Grant (Santen, Pfizer, Alcon, Senju, Kowa), Speaker fee (Santen, Senju, Kowa).

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Corresponding Author: Akiko Miki

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Ueda, K., Miki, A., Nakai, S. et al. Prediction of severe retinopathy of prematurity using the weight gain, insulin-like growth factor 1, and neonatal retinopathy of prematurity algorithm in a Japanese population of preterm infants. Jpn J Ophthalmol 64, 223–227 (2020). https://doi.org/10.1007/s10384-019-00709-z

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  • DOI: https://doi.org/10.1007/s10384-019-00709-z

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