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REFERENCES
Krachmer JH, Feder RS, Belin MW. Keratoconus and related noninflammatory corneal thinning disorders. Surv Ophthalmol. 1984;28:293–322.
Rabinowitz YS. Keratoconus. Surv Ophthalmol. 1998;42:297–319.
Erie JC, Patel SV, McLaren JW, Nau CB, Hodge DO, Bourne WM. Keratocyte density in keratoconus: a confocal microscopy study(a). Am J Ophthalmol. 2002;134:689–95.
Ku JY, Niederer RL, Patel DV, Sherwin T, McGhee CN. Laser scanning in vivo confocal analysis of keratocyte density in keratoconus. Ophthalmology. 2008;115:845–50.
Niederer RL, Perumal D, Sherwin T, McGhee CN. Laser scanning in vivo confocal microscopy reveals reduced innervation and reduction in cell density in all layers of the keratoconic cornea. Invest Ophthalmol Vis Sci. 2008;49:2964–70.
Reinstein DZ, Silverman RH, Rondeau MJ, Coleman DJ. Epithelial and corneal thickness measurements by high-frequency ultrasound digital signal processing. Ophthalmology. 1994;101:140–6.
Reinstein DZ, Archer TJ, Gobbe M. Corneal epithelial thickness profile in the diagnosis of keratoconus. J Refract Surg. 2009;25:604–10.
Reinstein DZ, Gobbe M, Archer TJ, Silverman RH, Coleman DJ. Epithelial, stromal, and total corneal thickness in keratoconus: three-dimensional display with artemis very-high frequency digital ultrasound. J Refract Surg. 2010;26:259–71.
Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, et al. Optical coherence tomography. Science. 1991;254:1178–81.
Izatt JA, Hee MR, Swanson EA, Lin CP, Huang D, Schuman JS, et al. Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography. Arch Ophthalmol. 1994;112:1584–9.
Ramos JL, Li Y, Huang D. Clinical and research applications of anterior segment optical coherence tomography: a review. Clin Experiment Ophthalmol. 2009;37:81–9.
Maeda N. Optical coherence tomography for corneal diseases. Eye Contact Lens. 2010;36:254–9.
Li Y, Tan O, Brass R, Weiss JL, Huang D. Corneal epithelial thickness mapping by Fourier-domain optical coherence tomography in normal and keratoconic eyes. Ophthalmology. 2012;119:2425–33.
Rocha KM, Perez-Straziota CE, Stulting RD, Randleman JB. SD-OCT analysis of regional epithelial thickness profiles in keratoconus, postoperative corneal ectasia, and normal eyes. J Refract Surg. 2013;29:173–9.
Sandali O, El Sanharawi M, Temstet C, Hamiche T, Galan A, Ghouali W, et al. Fourier-domain optical coherence tomography imaging in keratoconus: a corneal structural classification. Ophthalmology. 2013;120:2403–12.
Maeda N, Klyce SD, Smolek MK, Thompson HW. Automated keratoconus screening with corneal topography analysis. Invest Ophthalmol Vis Sci. 1994;35:2749–57.
Maeda N, Fujikado T, Kuroda T, Mihashi T, Hirohara Y, Nishida K, et al. Wavefront aberrations measured with Hartmann-Shack sensor in patients with keratoconus. Ophthalmology. 2002;109:1996–2003.
Araki-Sasaki K, Hirano K, Osakabe Y, Kuroda M, Kitagawa K, Mishima H, et al. Classification of secondary corneal amyloidosis and involvement of lactoferrin. Ophthalmology. 2013;120:1166–72.
Mohamed S, Lee GK, Rao SK, Wong AL, Cheng AC, Li EY, et al. Repeatability and reproducibility of pachymetric mapping with Visante anterior segment-optical coherence tomography. Invest Ophthalmol Vis Sci. 2007;48:5499–504.
Wang J, Fonn D, Simpson TL, Jones L. Relation between optical coherence tomography and optical pachymetry measurements of corneal swelling induced by hypoxia. Am J Ophthalmol. 2002;134:93–8.
King-Smith PE, Fink BA, Fogt N, Nichols KK, Hill RM, Wilson GS. The thickness of the human precorneal tear film: evidence from reflection spectra. Invest Ophthalmol Vis Sci. 2000;41:3348–59.
Wang J, Fonn D, Simpson TL, Jones L. Precorneal and pre- and postlens tear film thickness measured indirectly with optical coherence tomography. Invest Ophthalmol Vis Sci. 2003;44:2524–8.
Wang J, Aquavella J, Palakuru J, Chung S, Feng C. Relationships between central tear film thickness and tear menisci of the upper and lower eyelids. Invest Ophthalmol Vis Sci. 2006;47:4349–55.
Scroggs MW, Proia AD. Histopathological variation in keratoconus. Cornea. 1992;11:553–9.
Eagle RCJr, Dillon EC, Laibson PR. Compensatory epithelial hyperplasia in human corneal disease. Trans Am Ophthalmol Soc. 1992;90:265–73.
Patel S, Marshall J, Fitzke FWIII. Refractive index of the human corneal epithelium and stroma. J Refract Surg. 1995;11:100–5.
Simon G, Ren Q, Kervick GN, Parel JM. Optics of the corneal epithelium. Refract Corneal Surg. 1993;9:42–50.
Wang J, Thomas J, Cox I, Rollins A. Noncontact measurements of central corneal epithelial and flap thickness after laser in situ keratomileusis. Invest Ophthalmol Vis Sci. 2004;45:1812–6.
Sin S, Simpson TL. The repeatability of corneal and corneal epithelial thickness measurements using optical coherence tomography. Optom Vis Sci. 2006;83:360–5.
Tao A, Wang J, Chen Q, Shen M, Lu F, Dubovy SR, et al. Topographic thickness of Bowman’s layer determined by ultra-high resolution spectral domain-optical coherence tomography. Invest Ophthalmol Vis Sci. 2011;52:3901–7.
Francoz M, Karamoko I, Baudouin C, Labbe A. Ocular surface epithelial thickness evaluation with spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2011;52:9116–23.
Haque S, Jones L, Simpson T. Thickness mapping of the cornea and epithelium using optical coherence tomography. Optom Vis Sci. 2008;85:E963–76.
Zhou W, Stojanovic A. Comparison of corneal epithelial and stromal thickness distributions between eyes with keratoconus and healthy eyes with corneal astigmatism ≥ 2.0 D. PLoS ONE. 2014;9:e85994.
Feng MT, Belin MW, Ambrósio R Jr, Grewal SP, Yan W, Shaheen MS, et al. International values of corneal elevation in normal subjects by rotating Scheimpflug camera. J Cataract Refract Surg. 2011;37:1817–21.
Reinstein DZ, Archer TJ, Gobbe M, Silverman RH, Coleman DJ. Epithelial thickness in the normal cornea: three-dimensional display with Artemis very high-frequency digital ultrasound. J Refract Surg. 2008;24:571–81.
Fuchihata M, Maeda N, Toda R, Koh S, Fujikado T, Nishida K. Characteristics of corneal topographic and pachymetric patterns in patients with pellucid marginal corneal degeneration. Jpn J Ophthalmol. 2014;58:131–8.
Acknowledgments
Publication of this article was supported in part by Grant-in-Aid no. 24592669 for Scientific Research (to N.M.) from the Japanese Ministry of the Education, Culture, Sports, Science, and Technology. The authors would like to thank Enago (www.enago.jp) for the English language review.
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Maeda, N., Nakagawa, T., Higashiura, R. et al. Evaluation of corneal epithelial and stromal thickness in keratoconus using spectral-domain optical coherence tomography. Jpn J Ophthalmol 58, 389–395 (2014). https://doi.org/10.1007/s10384-014-0338-0
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DOI: https://doi.org/10.1007/s10384-014-0338-0