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Clinical and histopathological features of a suspected case of fish-eye disease

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To report the clinical and histopathological features of a suspected case of fish-eye disease.

Case

A 57-year-old man presented with blurred vision. The best corrected visual acuity was 0.8 OD and 1.0 OS. The patient had no family history of cloudy cornea. Slit-lamp examination revealed massive bilateral diffuse corneal clouding. Because of progressive corneal clouding during the previous 3 years, we performed penetrating keratoplasty and cataract surgery. He had a low-plasma, high-density lipoprotein (HDL) concentration. Histopathologically, numerous small vacuoles were dispersed, especially in the anterior corneal stroma. An electron microscope revealed distinct 0.2–3.0-μm lipid vacuoles with a conserved stromal structure.

Conclusion

We suspected a case of sporadic fish-eye disease in a Japanese patient. Lipid deposition needs to be considered as a cause of diffuse corneal opacity.

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Authors and Affiliations

  1. Department of Ophthalmology, Kansai Medical University, 2–3–1 Shinmachi, Hirakata, Osaka, 573-1191, Japan

    Hiroko Tateno, Makoto Taomoto, Nobuo Jo & Kanji Takahashi

  2. Department of Pathology, Kansai Medical University, Hirakata, Japan

    Yoshiko Uemura

Authors
  1. Hiroko Tateno
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  2. Makoto Taomoto
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  3. Nobuo Jo
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  4. Kanji Takahashi
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  5. Yoshiko Uemura
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Corresponding author

Correspondence to Hiroko Tateno.

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Tateno, H., Taomoto, M., Jo, N. et al. Clinical and histopathological features of a suspected case of fish-eye disease. Jpn J Ophthalmol 56, 453–457 (2012). https://doi.org/10.1007/s10384-012-0164-1

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  • DOI: https://doi.org/10.1007/s10384-012-0164-1

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