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A Case of Multiple Sclerosis with Homonymous Hemianopia Examined by Positron Emission Tomography

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Abstract

Background

To demonstrate the efficacy of positron emission tomography (PET) for examining multiple sclerosis (MS) patients with hemianopia.

Case

A 20-year-old man visited us with a complaint of left homonymous hemianopia and headache.

Observations

The patient’s visual acuity was 1.2 (n.c.) OD and 0.9 (1.0) OS. Magnetic resonance imaging (MRI) showed a mass in the temporoparietal lobe. A pathological diagnosis of MS was made by brain biopsy. Low glucose metabolism in the lesion and visual cortex was observed by PET with 18F-fluorodeoxy glucose. PET with 11C-flumazenyl revealed a reduction of 11C-uptake in the demyelinated optic radiation, and only a slight reduction of 11C-uptake in the primary visual cortex. The results of 11C-flumazenyl PET suggested a slight reduction of neuronal density. In 2 years, the visual field recovered to the normal state.

Conclusion

PET can be a useful tool for estimating the visual outcome of patients with hemianopia in MS. Jpn J Ophthalmol 2004;48:591–593 © Japanese Ophthalmological Society 2004

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Authors and Affiliations

  1. Department of Ophthalmology and Visual Science, Postgraduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

    Hideki Murai, Motohiro Kiyosawa, Yukihisa Suzuki & Shoichi Mizoguchi

  2. PET Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

    Kenji Ishii

  3. Department of Neurology, Postgraduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

    Kinya Ishikawa

  4. Department of Pathology, Postgraduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan

    Takumi Akashi

Authors
  1. Hideki Murai
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  2. Motohiro Kiyosawa
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  3. Yukihisa Suzuki
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  4. Shoichi Mizoguchi
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  5. Kenji Ishii
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  6. Kinya Ishikawa
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  7. Takumi Akashi
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Corresponding author

Correspondence to Motohiro Kiyosawa.

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Murai, H., Kiyosawa, M., Suzuki, Y. et al. A Case of Multiple Sclerosis with Homonymous Hemianopia Examined by Positron Emission Tomography. Jpn J Ophthalmol 48, 591–593 (2004). https://doi.org/10.1007/s10384-004-0128-1

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  • DOI: https://doi.org/10.1007/s10384-004-0128-1

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