Zusammenfassung
GRUNDLAGEN: Der therapeutische Einsatz der Radiofrequenzenergie (RF) in der Medizin nimmt zu. Diese Arbeit beschreibt 4 neue RF-Instrumente für Chirurgie, Endoskopie und interventioneller Radiologie. METHODIK: Die 4 Instrumente sind: 1) Endoblate zur endoskopischen RF-Therapie beim Rektumkarzinom; 2) Hexablate, ein bipolares RF-Instrument zur Behandlung des Hepatoms; 3) VesCoag, ein bipolarer RF-Katheter zum interventionell-radiologischem Verschluss von Tumorgefäßen der Leber und 4) EndoHPB, ein endoskopischer bipolarer RF-Katheter zur endobiliären Ablation, derzeit im Schweiemodel getestet. ERGEBNISSE: Endoblate, Hexablate and VesCoag zeigten im klinischen Einsatz keine technischen Probleme und unerwünschte Nebenwirkungen. Alle wurden bipolar verwendet bis auf VesCoag, welches nur monopolar Effizienz bei der Gefäßversiegelung zeigte. Bei EndoHPB zeigte sich im Schweinemodell, dass 5–10 Watt für 2 Minuten die ideale Einstellung war. Eine klinische Studie untersucht derzeit den Einsatz bei malignem Verschlussikterus. SCHLUSSFOLGERUNGEN: Die RF-Instrumente stellen eine faszinierende Entwicklung dar, welche vielversprechende therapeutische Methoden in Endoskopie, Chirurgie und interventioneller Radiologie erwarten lassen.
Summary
BACKGROUND: The potential applications of radiofrequency (RF) energy in medicine are an expanding field. This paper describes the development and early results of the application of four novel radiofrequency devices in surgery, endoscopy and interventional radiology. METHODS: The four devices that were designed and have been assessed were 1) Endoblate: a bipolar RF catheter for endoscopic use which was assessed in patients with rectal tumors, 2) Hexablate: a bipolar RF ablation/aspiration device which was used to treat liver cancers, 3) VesCoag: a bipolar RF catheter for endovascular ablation which was used by interventional radiologists to seal the blood vessels of tumors within the liver and 4) EndoHPB: an endoscopic bipolar RF catheter for endobiliary ablation which so far has been assessed in a porcine model. RESULTS: In the pilot clinical studies on Endoblate, Hexablate and VesCoag, all the devices could be used in the clinical situation for which they had been designed. There were no technical problems and no serious adverse events associated with their use. All were used in bipolar mode apart from VesCoag, where it was found that a monopolar current was required for effective vessel sealing. For EndoHPB in the porcine model, it was determined that the ideal power setting was 5–10 watts for 2 min. A clinical trial is to be undertaken to determine whether this power setting is applicable for when EndoHPB is used in the management of malignant obstructive jaundice. CONCLUSIONS: It is an exciting time in the development of new RF instruments, and as they become more sophisticated their clinical applications will expand. These early data from the animal and pilot clinical studies are promising and larger studies with longer term follow-up needs to be undertaken to establish their true clinical worth.
References
Weber JC, Navarra G, Jiao LR, Nicholls JP, Jensen SL, Habib NA. New technique for liver resection using heat coagulative necrosis. Ann Surg 2002;236:560–3
Bachellier P, Ayav A, Pai M, Weber JC, Rosso E, Jaeck D, Habib NA, Jiao LR. Laparoscopic liver resection assisted with radiofrequency. Am J Surg 2007;193:427–30
Ayav A, Jiao L, Dickinson R, Nicholls J, Milicevic M, Pellicci R, Bachellier P, Habib N. Liver resection with a new multiprobe bipolar radiofrequency device. Arch Surg 2008;143:396–401
Ayav A, Bachellier P, Habib NA, Pellicci R, Tierris J, Milicevic M, Jiao LR. Impact of radiofrequency assisted hepatectomy for reduction of transfusion requirements. Am J Surg 2007;193:143–8
El-Gendi AM, Khorsandi SE, Pai M, Zacharoulis D, Nicholls JP, Spalding DRC, Jiao LR, Habib NA. Repeat Hepatic Resection using a Radiofrequency Assisted Technique. Dig Surg 2008; in press
Kiran RP, Pokala N, Burgess P. Use of laser for rectal lesions in poor-risk patients. Am J Surg 2004;188:708–13
Kimmey MB. Endoscopic methods (other than stents) for palliation of rectal carcinoma. J Gastrointest Surg 2004;8:270–3
Karoui M, Charachon A, Delbaldo C, et al. Stents for palliation of obstructive metastatic colon cancer: impact on management and chemotherapy administration. Arch Surg 2007;142:619–23
Fong Y, Fortner J, Sun RL, et al. Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Ann Surg 1999;230:309–18
Jiao LR, Hansen PD, Havlic R, et al. Clinical short-term results of radiofrequency ablation in primary and secondary liver tumors. Am J Surg 1999;177:303–6
Navarra G, Ayav A, Weber JC, et al. Short- and long-term results of intraoperative radiofrequency ablation of liver metastases. Int J Colorectal Dis 2005;20:521–8
U.S. Markets for Electrosurgical and Thermal Ablation Products Report. MedTech Insight #A556 July 2006 Chapter 4
Mulier S, Mulier P, Ni Y, et al. Complications of radiofrequency coagulation of liver tumors. Br J Surg 2002;89:1206–22
Kotoh K, Enjoji M, Arimura E, et al. Scattered and rapid intrahepatic recurrences after radio frequency ablation fo hepatocellular carcinoma. World J Gastroenterol 2005;11:6828–32
Angonese C, Baldan A, Cillo U, et al. Complications of radiofrequency thermal ablation in hepatocellular carcinoma: what about "explosive" spread? GENE (Gruppo Epatocarcinoma Nord-Est Hepatocarcinoma Group North East Italy). Gut 2006;55:435–6
Breedis C, Young G. The blood supply of neoplasms in the liver. Am J Pathol 1954;30:969–77
Meric F, Patt YZ, Curley SA, et al. Surgery after downstaging of unresectable hepatic tumors with intra-arterial chemotherapy. Ann Surg Oncol 2000;7:490–5
Cammà C, Schepis F, Orlando A, et al. Transarterial chemoembolization for unresectable hepatocellular carcinoma: meta-analysis of randomized controlled trials. Radiology 2002;224:47–54
Marelli L, Stigliano R, Triantos C, et al. Transarterial therapy for hepatocellular carcinoma: which technique is more effective? A systematic review of cohort and randomized studies. Cardiovasc Intervent Radiol 2007;30:6–25
Takayasu K, Moriyama N, Muramatsu Y, et al. Gallbladder infarction after hepatic artery embolization. AJR 1985;144:135–8
Kaassis M, Boyer J, Dumas R, et al. Plastic or metal stents for malignant stricture of the common bile duct? Results of a randomized prospective study. Gastrointest Endosc 2003;57:178–82
Zoepf T, Jakobs R, Arnold JC, Apel D, Riemann JF. Palliation of nonresectable bile duct cancer: improved survival after photodynamic therapy. Am J Gastroenterol 2005;100:2426–30
Mulier S, Ni Y, Jamart J, et al. Local recurrence after hepatic radiofrequency coagulation multivariate meta-analysis and review of contributing factors. Ann Surg 2005;242:158–71
Dietzek AM. Endovenous radiofrequency ablation for the treatment of varicose veins. Vascular 2007;15:255–61
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Khorsandi, S., Zacharoulis, D., Vavra, P. et al. The modern use of radiofrequency energy in surgery, endoscopy and interventional radiology. Eur Surg 40, 204–210 (2008). https://doi.org/10.1007/s10353-008-0427-8
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s10353-008-0427-8