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Robust imaging of hippocampal inner structure at 7T: in vivo acquisition protocol and methodological choices

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Abstract

Objective

Motion-robust multi-slab imaging of hippocampal inner structure in vivo at 7T.

Materials and methods

Motion is a crucial issue for ultra-high resolution imaging, such as can be achieved with 7T MRI. An acquisition protocol was designed for imaging hippocampal inner structure at 7T. It relies on a compromise between anatomical details visibility and robustness to motion. In order to reduce acquisition time and motion artifacts, the full slab covering the hippocampus was split into separate slabs with lower acquisition time. A robust registration approach was implemented to combine the acquired slabs within a final 3D-consistent high-resolution slab covering the whole hippocampus. Evaluation was performed on 50 subjects overall, made of three groups of subjects acquired using three acquisition settings; it focused on three issues: visibility of hippocampal inner structure, robustness to motion artifacts and registration procedure performance.

Results

Overall, T2-weighted acquisitions with interleaved slabs proved robust. Multi-slab registration yielded high quality datasets in 96 % of the subjects, thus compatible with further analyses of hippocampal inner structure.

Conclusion

Multi-slab acquisition and registration setting is efficient for reducing acquisition time and consequently motion artifacts for ultra-high resolution imaging of the inner structure of the hippocampus.

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Authors and Affiliations

  1. UPMC Univ Paris 06, UMR S 1127, ICM, Sorbonne Universités, 75013, Paris, France

    Linda Marrakchi-Kacem, Johanne Germain, Stéphane Lehéricy, Olivier Colliot & Marie Chupin

  2. Inserm, U1127, 75013, Paris, France

    Linda Marrakchi-Kacem, Johanne Germain, Stéphane Lehéricy, Olivier Colliot & Marie Chupin

  3. CNRS, UMR 7225, 75013, Paris, France

    Linda Marrakchi-Kacem, Johanne Germain, Stéphane Lehéricy, Olivier Colliot & Marie Chupin

  4. ICM, 75013, Paris, France

    Linda Marrakchi-Kacem, Johanne Germain, Stéphane Lehéricy, Olivier Colliot & Marie Chupin

  5. Inria Paris-Rocquencourt, 75013, Paris, France

    Linda Marrakchi-Kacem, Johanne Germain, Olivier Colliot & Marie Chupin

  6. Institut Supérieur de Biotechnologies de Sidi Thabet, Ariana-Tunis, Tunisia

    Linda Marrakchi-Kacem

  7. UNIRS, NeuroSpin, I2BM, DSV, CEA, Saclay, France

    Alexandre Vignaud & Cyril Poupon

  8. Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA

    Julien Sein & Pierre-François Van de Moortele

  9. Department of Neurology, University of Minnesota, Minneapolis, MN, USA

    Thomas R. Henry

  10. UNIACT, NeuroSpin, I2BM, DSV, CEA, Saclay, France

    Lucie Hertz-Pannier

  11. INSERM U1129, Paris, France

    Lucie Hertz-Pannier

  12. Paris-Descartes University, CEA, Gif sur Yvette, France

    Lucie Hertz-Pannier

  13. Centre de Neuro-Imagerie de Recherche CENIR, AP-HP, Hopital de la Pitie Salpetriere, Paris, France

    Stéphane Lehéricy

Authors
  1. Linda Marrakchi-Kacem
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  2. Alexandre Vignaud
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  3. Julien Sein
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  4. Johanne Germain
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  7. Lucie Hertz-Pannier
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  8. Stéphane Lehéricy
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  9. Olivier Colliot
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Corresponding author

Correspondence to Linda Marrakchi-Kacem.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Funding

This work was supported by ANR (project HM-TC, Grant no. ANR-09-EMER-006), France Alzheimer Association (project IRMA7), by the program “Investissements d’avenir” (Grant no. ANR-10-IAIHU-06) and by the CATI project (Fondation Plan Alzheimer).

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Informed consent was obtained from all individual participants included in the study.

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Marrakchi-Kacem, L., Vignaud, A., Sein, J. et al. Robust imaging of hippocampal inner structure at 7T: in vivo acquisition protocol and methodological choices. Magn Reson Mater Phy 29, 475–489 (2016). https://doi.org/10.1007/s10334-016-0552-5

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  • DOI: https://doi.org/10.1007/s10334-016-0552-5

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