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The expression of Twist in salivary adenoid cystic carcinoma and its clinicopathological significance

  • Published:
The Chinese-German Journal of Clinical Oncology

Abstract

Objective

The purpose of this study was to investigate the expression of Twist in salivary adenoid cystic carcinoma (SACC) and the relations between Twist expression and the clinicopathological characteristics.

Methods

The expression of Twist was examined immunohistochemically in 48 cases of SACC, 18 of pleomorphic adenoma and 10 of normal parotid gland. The relationship between Twist expression in SACC and the clinicopathological factors was analyzed.

Results

Twist expression was significantly higher in SACC tissues compared with pleomorphic adenomas and normal parotid gland tissues (P < 0.05). Twist expression levels in SACC were significantly associated with histological type, perineural invasion, postoperative recurrence, and distant metastasis (P < 0.05), rather than age, gender, tumor site, tumor size, or clinical staging (P > 0.05).

Conclusion

Twist expression may be associated with tumor cell differentiation, perineural invasion and metastasis of SACC. Twist expression is a potential prognostic factor for disease survival of SACC.

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Author information

Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, The Second People’s Hospital of Hefei, Hefei, 230011, China

    Molun Shen

  2. Department of Oral Medicine, Hefei Hospital of Stomatology, Hefei, 230001, China

    Yanli Wen

  3. Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China

    Chengge Hua

  4. Department of Oral and Maxillofacial Surgery, School & Hospital of Stomatology, Wenzhou Medical College, Wenzhou, 325027, China

    Molun Shen & Jin Xiao

Authors
  1. Molun Shen
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  2. Yanli Wen
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  3. Chengge Hua
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  4. Jin Xiao
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Corresponding author

Correspondence to Chengge Hua.

Additional information

Supported by a grant from Science and Technology Project of Wenzhou City (No. Y20090055).

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Shen, M., Wen, Y., Hua, C. et al. The expression of Twist in salivary adenoid cystic carcinoma and its clinicopathological significance. Chin. -Ger. J. Clin. Oncol. 9, 187–192 (2010). https://doi.org/10.1007/s10330-010-0028-4

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  • DOI: https://doi.org/10.1007/s10330-010-0028-4

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