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Tetracycline antibiotics in the environment: a review

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Abstract

Tetracycline antibiotics are one of the primarily antibiotics groups used for veterinary purposes, for human therapy and for agricultural purposes. Amongst the different antibiotics used, more attention is paid to tetracycline’s as it exhibits serious environmental problems including ecological risks and human health damages. Due to their extensive usage, most of the actual evidence suggests that tetracycline antibiotics are omnipresent compounds found in different ecological compartments. After medication, more than 70 % of tetracycline antibiotics are excreted and released in active form into the environment via urine and feces from humans and animals. Their highly hydrophilic character and low volatility have resulted in significant persistence in the aquatic environment. Very few studies describe the fate and toxicity of tetracycline antibiotics in the environment. Here, we review several important issues with regard to: (1) the toxicity of these compounds on aquatic and terrestrial organisms; (2) their estrogenic effects; (3) their behavior in different ecological systems and; (4) the by-products generated during water treatment. These antibiotics residues promote the development of antibiotic resistant microorganisms, which can induce adverse effect to human health by increasing the risk of certain infections. Based on recent research results, the occurrence of tetracycline antibiotics in the environment inhibits the growth of some terrestrial and aquatic species. Besides, the residual concentrations of such drugs could affect steroidogenic pathway and consequently may cause endocrine disruption of aquatic species. Most of the wastewater treatment plants are not capable of removing effectively the tetracycline antibiotics. Therefore, there is a need to develop alternative processes to remove them from waters. Advanced oxidation processes have been proposed as alternative methods to ensure higher degradation and mineralization of tetracycline antibiotics are present in waters.

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Acknowledgments

Sincere thanks are extended to the National Sciences and Engineering Research Council of Canada and Premier Tech Ltee for their financial support for this study.

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  1. Institut national de la recherche scientifique (INRS-Eau Terre et Environnement), Université du Quebec, 490 rue de la Couronne, Quebec City, Quebec, G1K 9A9, Canada

    R. Daghrir & P. Drogui

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  1. R. Daghrir
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  2. P. Drogui
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Correspondence to P. Drogui.

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Daghrir, R., Drogui, P. Tetracycline antibiotics in the environment: a review. Environ Chem Lett 11, 209–227 (2013). https://doi.org/10.1007/s10311-013-0404-8

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