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Le rôle du fenugrec dans la survenue d’anomalie de fermeture du tube neural : un signal d’alerte depuis le Maroc

The role of fenugreek in the occurrence of an anomaly of neural tube closure: Warning signal from Morocco

  • Toxicologie
  • Published:
Phytothérapie

Résumé

Le fenugrec compte parmi les plus anciennes plantes médicinales et culinaires, il est très utilisé au Maroc et en Méditerranée. En phytothérapie, les graines de la plante sont indiquées pour stimuler l’appétit chez la femme enceinte, pour soulager l’inflammation, pour traiter la dysenterie, la dyspepsie, la toux chronique, la bronchite, les névralgies, pour faciliter l’accouchement et comme galactogènes. Malheureusement, peu de données fondées sur des fondements scientifiques sont offertes par la littérature pour confirmer les vertus thérapeutiques attribuées à ces graines. Les premiers événements indésirables liés à la consommation de cette plante ont été déclarés entre le mois de mars et le mois d’août 2006 par le Centre marocain de pharmacovigilance; Skalli a rapporté huit cas de malformations (hydrocéphalie et spinabifida) coïncidant avec l’ingestion au cours de la grossesse de graines de fenugrec. Plusieurs travaux ont confirmé par la suite ce fait clinique. Le but de notre travail est de rapporter les données locales et nationales sur la relation entre la consommation du fenugrec durant la grossesse et l’apparition de malformations du tube neural en s’appuyant sur certaines études qui confirment cette relation.

Abstract

Fenugreek is among the oldest medicinal and culinary plants. It is widely used in Morocco and the Mediterranean area. In herbal medicine, the seeds of this plant are shown to stimulate appetite in pregnant women to treat inflammation, dysentery, dyspepsia, chronic cough, bronchitis, neuralgia, and facilitate childbirth and also as galactagogue. Unfortunately, few scientific data are available from the literature to confirm therapeutic properties of fenugreek. The early adverse events related to the consumption of this plant were reported between March and August 2006 by the Moroccan Pharmacovigilance Centre; Skalli reported eight cases of malformations (hydrocephalus and spina bifida) coinciding with fenugreek ingestion during pregnancy. A lot of studies have subsequently confirmed this clinical fact. The aim of this study is to report local and national data on the relationship between the consumption of fenugreek during pregnancy and the appearance of neural tube defects based on studies that confirm this relationship.

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Authors and Affiliations

  1. Service de néonatologie, hôpital Al-Farabi, centre hospitalier universitaire Mohammed-VI, Oujda, Maroc

    A. Es Seddiki, S. Messaouidi & R. Amrani

  2. Faculté de médecine et de pharmacie d’Oujda, université Mohammed-I, Oujda, Maroc

    A. Es Seddiki, S. Messaouidi & R. Amrani

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  1. A. Es Seddiki
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  2. S. Messaouidi
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  3. R. Amrani
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Correspondence to A. Es Seddiki.

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Es Seddiki, A., Messaouidi, S. & Amrani, R. Le rôle du fenugrec dans la survenue d’anomalie de fermeture du tube neural : un signal d’alerte depuis le Maroc. Phytothérapie 15, 155–158 (2017). https://doi.org/10.1007/s10298-017-1128-x

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  • DOI: https://doi.org/10.1007/s10298-017-1128-x

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