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Effet de l’extrait éthanolique des écorces du tronc de Buchholzia coriacea sur quelques paramètres asthmatiques chez le rat

Effect of ethanolic extract of trunk bark of Buchholzia coriacea on some asthmatic parameters in rats

  • Pharmacognosie
  • Published:
Phytothérapie

Résumé

Buchholzia coriacea (Capparidacea), est une espèce utilisée en médecine traditionnelle dans le bassin de Congo pour le soulagement des affections courantes dont les maladies inflammatoires, l’asthme, les douleurs, la fièvre, les plaies, les abcès. Le présent travail a pour l’objectif d’étudier l’écorce de Buchholzia coriacea sur quelques paramètres asthmatiques chez les rats wistar. L’extrait éthanolique de Buchholzia coriacea est administré aux rats sensibilisés à ovalbumine. La migration leucocytaire et l’infiltration du liquide plasmatique dans les voies respiratoires ont été évaluées. Par ailleurs, l’extrait est testé sur la trachée artère isolée de rat précontractée avec la métacholine. Les résultats obtenus montrent que l’extrait éthanolique de Buchholzia coriacea (200 et 400 mg/kg) a empêché de manière significative l’infiltration des cellules leucocytaires et du liquide plasmatique dans les voies respiratoires des rats sensibilisés. L’extrait de Buchholzia coriacea, en concentrations cumulées a relâché la trachée artère préalablement contractée par la métacholine. On peut conclure que l’extrait éthanolique de l’écorce du tronc de Buchholzia coriacea a des propriétés antiasthmatiques. D’autres investigations sont nécessaires pour élucider les mécanismes d’action.

Abstract

Buchholzia coriacea (Capparidacea) is used in traditional medicine in the Congo Basin to alleviate common ailments including inflammatory diseases, asthma, pain, fever, wounds, abscesses. The present investigation aims to study the bark of Buchholzia coriacea on asthma parameters in Wistar rats. The ethanol extract of Buchholzia coriacea is administered to ovalbumin sensitized rats. Leukocyte migration and infiltration of plasmatic liquid into the airways were evaluated. Moreover, the extract is tested in the isolated trachea of rat contracted with metacholine. The results show that the ethanol extract of Buchholzia coriacea (200 and 400 mg/kg) inhibited significantly the leukocyte infiltration and plasma extravasations into the airways of sensitized rats. Extract of the bark of Buchholzia coriacea, at cumulative concentrations reduces the isolated trachea previously contracted by metacholine. We conclude that the ethanol extract of the bark of Buchholzia coriacea has antiasthmatic properties. Further investigations are needed to elucidate the mechanisms of action.

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Author information

Authors and Affiliations

  1. Département des sciences naturelles, École normale Supérieure, université Marien Ngouabi Congo, Brazzaville, Congo

    C. Epa, C. J. Morabandza, M. G. Okiemy-AKeli, R. P. Ongoka & A. A. Abena

  2. Département de physiologie végétale, Faculté des sciences, université Marien Ngouabi, Brazzaville, Congo

    Attibayeba

  3. Laboratoire de physiologie/pharmacologie des substances naturelles, Faculté des sciences, Université de Lomé, Lomé, Togo

    A. Agbonon & M. Gbeassor

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  1. C. Epa
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  2. Attibayeba
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  3. A. Agbonon
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  4. C. J. Morabandza
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  8. M. Gbeassor
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Correspondence to C. Epa.

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Epa, C., Attibayeba, Agbonon, A. et al. Effet de l’extrait éthanolique des écorces du tronc de Buchholzia coriacea sur quelques paramètres asthmatiques chez le rat. Phytothérapie 14, 309–314 (2016). https://doi.org/10.1007/s10298-015-1002-7

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  • DOI: https://doi.org/10.1007/s10298-015-1002-7

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