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Intestinal obstruction associated with oral midodrine

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Abstract.

We report a case of severe ileus possibly related to midodrine. To our knowledge, this case report is the first one suggesting an inhibitory effect of midodrine on intestinal motility. The potential pharmacological mechanisms leading to this adverse drug reaction are discussed below.

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Authors and Affiliations

  1. Service de Pharmacologie Clinique et Centre Midi-Pyrénées de Pharmacovigilance, de Pharmacoépidémiologie et d’Information sur le Médicament, Faculté de Médecine, Toulouse, France

    Atul Pathak, Pascaline Debats, Jean-Louis Montastruc &  Jean-Michel Senard

  2. Service de Cardiologie, CHU de Rangueil, Toulouse, France

    Michel Galinier

  3. Laboratoire de Pharmacologie Médicale et Clinique, Faculté de Médecine, 7202, 37 allées Jules Guesde, 31073, Toulouse Cedex 7, France

    Jean-Michel Senard

Authors
  1. Atul Pathak
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  2. Pascaline Debats
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  3. Michel Galinier
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  4. Jean-Louis Montastruc
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  5. Jean-Michel Senard
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Corresponding author

Correspondence to Jean-Michel Senard.

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Pathak, A., Debats, P., Galinier, M. et al. Intestinal obstruction associated with oral midodrine. Clin Auton Res 14, 202–203 (2004). https://doi.org/10.1007/s10286-004-0176-0

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  • DOI: https://doi.org/10.1007/s10286-004-0176-0

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