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Préservation de la fertilité masculine

Male fertility preservation

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Oncologie

Abstract

The incidence of cancer increases and affects more and more young patients. On the other hand, survival rates also increase, but often at the price of infertility induced by the gonadal toxicity of many treatments and a risk of mutagenicity. The techniques of semen cryopreservation are easy and results obtained after utilization of cryopreserved semen for assisted reproduction (IUI, IVF, or intracytoplasmic sperm injection [ICSI]) are satisfactory. The information of a patient about the possibilities of cryopreservation of fertility prior to the use of potentially sterilizing treatment is a legal obligation for every physician. The improvement of quality of life after healing must encourage oncologists to propose fertility preservation to their patients, which offers a very reasonable chance of later paternity.

Résumé

L’incidence des cancers augmente et concerne des sujets de plus en plus jeunes. En parallèle, les taux de survie augmentent mais souvent au prix d’une stérilité induite par la gonadotoxicité de nombreux traitements et un risque de mutagénicité. Les techniques de préservation sont simples et les résultats obtenus après réutilisation en Assistance médicale à la procréation (AMP) sont satisfaisants. L’information du patient sur les possibilités de préservation de la fertilité est une obligation légale pour tout médecin avant le démarrage d’un traitement potentiellement stérilisant. L’amélioration de la qualité de vie après la guérison doit également inciter les oncologues à proposer à leurs patients une telle préservation afin de leur offrir des chances suffisantes de paternité ultérieure.

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Authors and Affiliations

  1. Pôle de gynécologie-obstétrique et reproduction, laboratoire de biologie de la reproduction-Cecos, Professeur Grillo, AP-HM La Conception, 147, boulevard Baille, F-13005, Marseille, France

    J. Saias-Magnan, J. Perrin, C. Metzler-Guillemain & J. -M. Grillo

  2. Pôle de digestif et gynécologie-obstétrique, CHU de Nice, hôpital Archet-II, Professeur Bongain, université de Nice-Sophia-Antipolis, 151, route Saint-Antoine-de-Ginestière, F-06200, Nice, France

    J. Delotte & I. Fatfouta

  3. Pôle de gynécologie-obstétrique et reproduction, AP-HM La Conception, Professeur Gamerre, 147, boulevard Baille, F-13005, Marseille, France

    B. Courbière

  4. Pôle de biologie-pathologie, laboratoire de biologie de la reproduction-Cecos, CHU de Nice, hôpital Archet-II, Professeur Michiels, université de Nice-Sophia-Antipolis, 151, route Saint-Antoine-de-Ginestière, F-06200, Nice, France

    S. Lattes & E. Thibault

  5. Laboratoire de biogenotoxicologie santé humaine et environnement, institut méditerranéen de biodiversité et d’écologie UMR 7263, faculté de médecine, Aix-Marseille université, fédération de recherche CNRS 3098-ECCOREV, 27, boulevard Jean-Moulin, F-13385, Marseille cedex 05, France

    J. Perrin & B. Courbière

  6. Inserm UMR 910, génétique et génomique fonctionnelle, faculté de médecine Timone, Aix-Marseille université, 27, boulevard J.-Moulin, F-13385, Marseille cedex 05, France

    C. Metzler-Guillemain

Authors
  1. J. Saias-Magnan
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  2. J. Perrin
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  3. C. Metzler-Guillemain
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  4. J. Delotte
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  5. B. Courbière
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  6. I. Fatfouta
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  7. S. Lattes
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  8. J. -M. Grillo
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  9. E. Thibault
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Corresponding author

Correspondence to J. Saias-Magnan.

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Saias-Magnan, J., Perrin, J., Metzler-Guillemain, C. et al. Préservation de la fertilité masculine. Oncologie 15, 225–230 (2013). https://doi.org/10.1007/s10269-013-2286-6

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  • DOI: https://doi.org/10.1007/s10269-013-2286-6

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