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Radiation-induced malignant fibrous histiocytoma of the maxilla

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Abstract

Malignant fibrous histiocytoma (MFH) originates from primitive mesenchymal cells and has the capacity for dual histiocytic and fibroblastic differentiation. We report on an MFH of the left maxilla that developed in a 79-year old woman 20 years after surgery and radiation for squamous cell carcinoma (SCC). Postoperative radiotherapy with 70 Gy was administered for a primary neoplasm of SCC of the left maxilla to a localized field through two lateral ports. This secondary neoplasm arose at the site of tumor resection (partial maxillectomy) within the irradiated field, and was resected. The development of sarcomas is a recognized complication of radiation therapy. The final diagnosis after the operation was MFH. The patient died of tumor recurrence at the skull base and within the cranium, 19 months after the operation. Radiation-induced sarcoma is well known, but radiation-induced MFH is relatively rare in the head and neck region. The details of this case are presented with a review of literature.

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Acknowledgments

The authors express their gratitude to Mr. C.W.P. Reynolds, and Professor J. Patrick Barron, of the Department of International Medical Communications of Tokyo Medical University for their careful revision of the English of this manuscript.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, Tokyo Medical University, 6-7-1, Nishishinjuku, Shinjukuku, Tokyo, 160-0023, Japan

    Takafumi Satomi, Masato Watanabe, Tadayoshi Kaneko & Hiroshige Chiba

  2. Department of Diagnostic Pathology, Tokyo Medical University, 6-7-1, Nishishinjuku, Shinjukuku, Tokyo, 160-0023, Japan

    Jun Matsubayashi & Toshitaka Nagao

Authors
  1. Takafumi Satomi
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  2. Masato Watanabe
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  3. Tadayoshi Kaneko
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  4. Jun Matsubayashi
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  5. Toshitaka Nagao
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  6. Hiroshige Chiba
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Correspondence to Takafumi Satomi.

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Satomi, T., Watanabe, M., Kaneko, T. et al. Radiation-induced malignant fibrous histiocytoma of the maxilla. Odontology 99, 203–208 (2011). https://doi.org/10.1007/s10266-011-0001-x

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