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Specimen-specific predictions of contact stress under physiological loading in the human hip: validation and sensitivity studies

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Abstract

Hip osteoarthritis may be initiated and advanced by abnormal cartilage contact mechanics, and finite element (FE) modeling provides an approach with the potential to allow the study of this process. Previous FE models of the human hip have been limited by single specimen validation and the use of quasi-linear or linear elastic constitutive models of articular cartilage. The effects of the latter assumptions on model predictions are unknown, partially because data for the instantaneous behavior of healthy human hip cartilage are unavailable. The aims of this study were to develop and validate a series of specimen-specific FE models, to characterize the regional instantaneous response of healthy human hip cartilage in compression, and to assess the effects of material nonlinearity, inhomogeneity and specimen-specific material coefficients on FE predictions of cartilage contact stress and contact area. Five cadaveric specimens underwent experimental loading, cartilage material characterization and specimen-specific FE modeling. Cartilage in the FE models was represented by average neo-Hookean, average Veronda Westmann and specimen- and region-specific Veronda Westmann hyperelastic constitutive models. Experimental measurements and FE predictions compared well for all three cartilage representations, which was reflected in average RMS errors in contact stress of less than 25 %. The instantaneous material behavior of healthy human hip cartilage varied spatially, with stiffer acetabular cartilage than femoral cartilage and stiffer cartilage in lateral regions than in medial regions. The Veronda Westmann constitutive model with average material coefficients accurately predicted peak contact stress, average contact stress, contact area and contact patterns. The use of subject- and region-specific material coefficients did not increase the accuracy of FE model predictions. The neo-Hookean constitutive model underpredicted peak contact stress in areas of high stress. The results of this study support the use of average cartilage material coefficients in predictions of cartilage contact stress and contact area in the normal hip. The regional characterization of cartilage material behavior provides the necessary inputs for future computational studies, to investigate other mechanical parameters that may be correlated with OA and cartilage damage in the human hip. In the future, the results of this study can be applied to subject-specific models to better understand how abnormal hip contact stress and contact area contribute to OA.

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Acknowledgments

Financial support from National Institutes of Health #R01AR05334 and #R01GM083925 is gratefully acknowledged. The authors thank Greg Stoddard for statistical advice and Gerard Ateshian (Columbia University) for guidance regarding the protocol for cartilage material testing.

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Authors and Affiliations

  1. Department of Bioengineering, University of Utah, 72 South Central Campus Dr., Room 3750, Salt Lake City, UT, 84112, USA

    Corinne R. Henak, Ashley L. Kapron, Andrew E. Anderson, Benjamin J. Ellis, Steve A. Maas & Jeffrey A. Weiss

  2. Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT, 84112, USA

    Corinne R. Henak, Andrew E. Anderson, Benjamin J. Ellis, Steve A. Maas & Jeffrey A. Weiss

  3. Department of Orthopedics, University of Utah, Salt Lake City, UT, 84108, USA

    Ashley L. Kapron, Andrew E. Anderson & Jeffrey A. Weiss

  4. Department of Physical Therapy, University of Utah, Salt Lake City, UT, 84108, USA

    Andrew E. Anderson

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  1. Corinne R. Henak
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Correspondence to Jeffrey A. Weiss.

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Henak, C.R., Kapron, A.L., Anderson, A.E. et al. Specimen-specific predictions of contact stress under physiological loading in the human hip: validation and sensitivity studies. Biomech Model Mechanobiol 13, 387–400 (2014). https://doi.org/10.1007/s10237-013-0504-1

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