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Effects of serum albumin and glycated albumin levels on performance of the Japanese GFR equation based on serum cystatin C

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Abstract

Background

We reported that both serum albumin (Alb) and glycated albumin (GA) levels influenced the performance of the Japanese GFR equation based on serum creatinine. In the present study, we studied the effects of both markers on the estimated GFR by Japanese GFR equation based on serum cystatin C (Eq-cys).

Methods

715 Japanese subjects were included. GFR was measured by inulin renal clearance (Cin). Correlations between estimated GFR by Eq-cys (eGFRcys) and Cin were evaluated in subjects stratified by GA (GA-1: GA ≤ 16.3 % and GA-2: GA ≥ 16.4 %) and Alb levels (Alb-1: Alb ≤ 3.5 g/dl and Alb-2: Alb ≥ 3.6 g/dl).

Results

Correlation coefficients between eGFRcys and Cin were 0.863, 0.919, 0.948 and 0.974 in GA-1, GA-2, Alb-1 and Alb-2, respectively. Slopes (95 % confidential interval) of the regression lines with zero intercepts were 1.014 (0.993–1.035), 0.989 (0.944–1.033), 1.019 (0.970–1.068) and 1.011 (0.990–1.031), respectively. The slopes were not significantly different from 1.0, suggesting that Eq-cys performed well in subjects at wide spectrum of GA and Alb levels. Single regression analysis of GA on eGFRcys/GFR was not significant in total subjects and subjects with GA > 12.4 %. Single regression analysis of Alb on eGFRcys/GFR was significant in total subjects, but the correlation coefficient was very low (r = 0.08, p = 0.03). Multiple regression analysis showed that Alb and GA were not significantly associated with eGFRcys/Cin in subjects with GA > 12.4 %. These results suggested that both parameters were not important factors affecting the performance of Eq-cys.

Conclusion

Performance of Eq-cys was well irrespective of GA and Alb levels. Both parameters were not important factors affecting the estimated GFR by Eq-cys.

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Acknowledgments

This study was supported in part by the grant from the Japanese Society of Nephrology and JSPS KAKENHI Grant Number 25305029, Japan.

Conflict of interest

All the authors have declared no competing interest.

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Authors and Affiliations

  1. Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Osaka, 565-0871, Japan

    Masaru Horio

  2. Nakayamadera Imai Clinic, Takarazuka, Japan

    Enyu Imai

  3. Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Yoshinari Yasuda

  4. Department of CKD Initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Yoshinari Yasuda & Seiichi Matsuo

  5. Third Department of Medicine, Fukushima Medical University, Fukushima, Japan

    Tsuyoshi Watanabe

  6. Division of Nephrology, Kanazawa Medical University School of Medicine, Uchinada, Japan

    Hitoshi Yokoyama

  7. Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Okayama, Japan

    Hirofumi Makino

Authors
  1. Masaru Horio
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  2. Enyu Imai
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  3. Yoshinari Yasuda
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  4. Tsuyoshi Watanabe
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  5. Hitoshi Yokoyama
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  6. Hirofumi Makino
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  7. Seiichi Matsuo
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Corresponding author

Correspondence to Masaru Horio.

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Horio, M., Imai, E., Yasuda, Y. et al. Effects of serum albumin and glycated albumin levels on performance of the Japanese GFR equation based on serum cystatin C. Clin Exp Nephrol 19, 626–630 (2015). https://doi.org/10.1007/s10157-014-1038-2

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  • DOI: https://doi.org/10.1007/s10157-014-1038-2

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