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Does posttransplant anemia at 6 months affect long-term outcome of live-donor kidney transplantation? A single-center experience

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Abstract

Background/Aims

Posttransplantation anemia (PTA) frequently occurs. We aimed to assess the prevalence of anemia at 6 months of transplantation in patients under different protocols of immunosuppression, and to determine the impact of anemia on long-term patient and graft survival.

Methods

We included 832 renal transplant recipients who were categorized at 6 months according to hemoglobin (Hb) level into two groups: the first group, with Hb >13 g/dl in males and >12 g/dl in females (group I, 385 cases); and the second group, with Hb <13 g/dl in males and <12 g/dl in females (group II, 447 cases). We compared the two groups regarding posttransplant complications as well as patient and graft survival.

Results

Although there was no significant difference between the two groups regarding acute rejection episodes, chronic allograft nephropathy was significantly higher in the anemic group. Other posttransplant medical complications were comparable in both groups. Graft survival was significantly higher in the nonanemic group. However, no difference in patient survival was detected.

Conclusion

From this study, we can conclude that prevalence of PTA is high, especially in females and those receiving calcineurine inhibitors (CNI) and mycophenolate mofetil (MMF), and that it was associated with poorer graft outcome but with no effect on patient survival.

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Author information

Authors and Affiliations

  1. Urology and Nephrology Center, Mansoura University, 17 gomhoreya at Mansoura, Mansoura, Egypt

    Osama Gheith, Ehab Wafa, Nabil Hassan, Amani Mostafa, Hussein A. Sheashaa, Khaled Mahmoud, Ahmed Shokeir & Mohamed A. Ghoneim

Authors
  1. Osama Gheith
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  2. Ehab Wafa
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  3. Nabil Hassan
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  4. Amani Mostafa
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  5. Hussein A. Sheashaa
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  6. Khaled Mahmoud
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  7. Ahmed Shokeir
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  8. Mohamed A. Ghoneim
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Correspondence to Osama Gheith.

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Gheith, O., Wafa, E., Hassan, N. et al. Does posttransplant anemia at 6 months affect long-term outcome of live-donor kidney transplantation? A single-center experience. Clin Exp Nephrol 13, 361–366 (2009). https://doi.org/10.1007/s10157-009-0171-9

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  • DOI: https://doi.org/10.1007/s10157-009-0171-9

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