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The characteristics of relapse in adult-onset minimal-change nephrotic syndrome

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Abstract

Background

Although minimal-change nephrotic syndrome (MCNS) is highly steroid-responsive, the frequency of relapses in some patients is high, necessitating the administration of repeated courses of prednisolone in high doses. It is, therefore, necessary to identify factors that can predict this increased risk of relapse in some patients in order to establish useful treatment methods to reduce the risk.

Methods

To clarify the factors that might increase the risk of relapses, the data of 82 Japanese adult patients with MCNS receiving treatment at our department were analyzed retrospectively. Of the total, 55 patients (67.1%) experienced relapse after showing an initial response. We divided the patients into two groups; namely, the nonrelapse group (n = 27) and the relapse group (n = 55), and compared the clinico-pathophysiological characteristics between the two groups.

Results

Significantly increased serum immunoglobulin E (IgE) levels (P = 0.0002) and increased frequency of steroid side effects were observed in the relapse group as compared to the nonrelapse group.

Conclusions

To develop effective therapeutic modalities, it is important to have a thorough understanding of the clinico-pathophysiological characteristics of MCNS patients showing relapse.

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Authors and Affiliations

  1. Department of Medicine, Kidney Center, Tokyo Women's Medical University, 8-1 Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan

    Takashi Takei, Minako Koike, Koichi Suzuki, Satsuki Shirota, Mitsuyo Itabashi, Shigeru Ohtsubo, Hidekazu Sugiura, Keiko Suzuki, Chiari Kojima, Masaki Takahashi, Jun Ino, Tetsuya Ogawa, Keiko Uchida, Ken Tsuchiya, Wako Yumura & Kosaku Nitta

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  1. Takashi Takei
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  2. Minako Koike
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  3. Koichi Suzuki
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  4. Satsuki Shirota
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  8. Keiko Suzuki
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  13. Keiko Uchida
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  14. Ken Tsuchiya
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  16. Kosaku Nitta
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Corresponding author

Correspondence to Takashi Takei.

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Takei, T., Koike, M., Suzuki, K. et al. The characteristics of relapse in adult-onset minimal-change nephrotic syndrome. Clin Exp Nephrol 11, 214–217 (2007). https://doi.org/10.1007/s10157-007-0484-5

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  • DOI: https://doi.org/10.1007/s10157-007-0484-5

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