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The predictive value of advanced lung cancer inflammation index for short-term outcomes and prognosis of colorectal cancer patients who underwent radical surgery

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Abstract

Purpose

The purpose of this study was to investigate the predictive value of advanced lung cancer inflammation index (ALI) for short-term outcomes and prognosis of colorectal cancer (CRC) patients who underwent radical surgery.

Methods

CRC patients who underwent radical resection were included from Jan 2011 to Jan 2020 in our single clinical centre. Short-term outcomes, overall survival (OS), and disease-free survival (DFS) were compared in different groups. Cox analysis was conducted to identify independent risk factors for OS and DFS.

Results

A total of 4010 patients who underwent radical CRC surgery were enrolled in the current study. As a result, the low ALI group had longer operation time (p = 0.02), more intra-operative blood loss (p < 0.01), longer postoperative hospital stay (p < 0.01), and more overall complications (p < 0.01). Moreover, ALI (p < 0.01, OR = 0.679, 95% CI = 0.578–0.798) was an independent risk factor for overall complications. As for survival, the low ALI group had worse OS in all TNM stages (p < 0.01), stage II (p < 0.01) and stage III (p < 0.01). Similarly, the low ALI group had worse DFS in all TNM stages (p < 0.01), stage II (p < 0.01), and stage III (p < 0.01). In Cox analysis, ALI was an independent risk factors for OS (p < 0.01, HR = 0.707, 95% CI = 0.589–0.849) and DFS (p < 0.01, HR = 0.732, 95% CI = 0.622–0.861).

Conclusion

Lower ALI was associated with more postoperative complications, worse OS, and DFS for CRC patients who underwent radical surgery. Furthermore, ALI was an independent risk factor for overall complications, OS, and DFS. Surgeons should pay close attention to patients with low ALI before surgery and make clinical strategies cautiously.

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Data availability

The datasets used and analysed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

We acknowledge all the authors whose publications are referred in our article.

Funding

This study is supported by CQMU Program for Youth Innovation in Future Medicine (W0190).

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Author notes

  1. Bin Zhang and Zi-Wei Li have contributed equally to this work.

Authors and Affiliations

  1. Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China

    Bin Zhang, Zi-Wei Li, Yue Tong, Chao Yuan, Xiao-Yu Liu, Zheng-Qiang Wei, Wei Zhang & Dong Peng

  2. Department of Gastrointestinal Surgery, Sichuan Mianyang 404 Hospital, Mianyang, 621000, China

    Bin Zhang

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Contributions

All authors contributed to data collection, data analysis, write the original draft. All authors have agreed on the journal to which the manuscript will be submitted, gave final approval of the version to be published, and agree to be accountable for all aspects of the work.

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Correspondence to Dong Peng.

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The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Ethical approval and informed consent

The study was approved by the ethics committee of our institution (The First Affiliated Hospital of Chongqing Medical University, 2022-135-2), and all patients signed informed consent. This study was conducted in accordance with the World Medical Association Declaration of Helsinki as well.

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Zhang, B., Li, ZW., Tong, Y. et al. The predictive value of advanced lung cancer inflammation index for short-term outcomes and prognosis of colorectal cancer patients who underwent radical surgery. Int J Clin Oncol 28, 1616–1624 (2023). https://doi.org/10.1007/s10147-023-02410-1

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