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CT-guided percutaneous radiofrequency ablation for lung metastases from colorectal cancer

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Abstract

Background

Radiofrequency ablation (RFA) can be a minimally invasive therapeutic option in patients with lung metastasis from colorectal caner. We aimed to elucidate the safety and survival benefit of computed tomography (CT)-guided percutaneous RFA for lung metastasis from colorectal cancer.

Methods

A total 188 lesions were ablated in 43 patients from 2005 to 2017. The clinicopathological and survival data of patients were collected retrospectively. The short- and long-term outcomes and prognostic factors were analyzed.

Results

Eight patients (18.6%) had viable extrapulmonary metastasis at RFA treatment. The median number of treated lung tumors was 2, and the median maximum diameter was 12 mm. Complications, such as pneumothorax, pleural effusion and subcutaneous emphysema, occurred in 24 (55.8%) patients. Although chest tube drainage for pneumothorax was needed in 6 patients (14.0%), there were no mortalities. Repeated RFA for lung recurrence after primary RFA was performed in 14 patients (32.6%). In a median follow-up of 24.3 months, the median progression-free and overall survival (OS) were 6.8 months and 52.7 months, respectively. The presence of extrapulmonary metastasis and a maximum tumors size of > 15 mm were independently associated with a worse disease-free survival and OS. The OS of patients who underwent repeated RFA was significantly better than that of patients who underwent RFA only once.

Conclusion

CT-guided percutaneous RFA for lung metastasis from colorectal cancer is a safe and effective procedure in patients not eligible for surgery, particularly for lesions smaller than 1.5 cm without extrapulmonary metastasis.

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Authors and Affiliations

  1. Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan

    Yukiharu Hiyoshi, Yuji Miyamoto, Yuki Kiyozumi, Hiroshi Sawayama, Kojiro Eto, Yohei Nagai, Masaaki Iwatsuki, Shiro Iwagami, Yoshifumi Baba, Naoya Yoshida & Hideo Baba

  2. Department of Diagnostic Imaging, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan

    Koichi Kawanaka & Yasuyuki Yamashita

Authors
  1. Yukiharu Hiyoshi
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  2. Yuji Miyamoto
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  3. Yuki Kiyozumi
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  4. Hiroshi Sawayama
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  5. Kojiro Eto
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  6. Yohei Nagai
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  9. Yoshifumi Baba
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  13. Hideo Baba
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Corresponding author

Correspondence to Hideo Baba.

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The authors declare that they have no conflict of interest.

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Cite this article

Hiyoshi, Y., Miyamoto, Y., Kiyozumi, Y. et al. CT-guided percutaneous radiofrequency ablation for lung metastases from colorectal cancer. Int J Clin Oncol 24, 288–295 (2019). https://doi.org/10.1007/s10147-018-1357-5

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  • DOI: https://doi.org/10.1007/s10147-018-1357-5

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