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Intraoperative radiotherapy for extremity soft-tissue sarcomas: can long-term local control be achieved?

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Abstract

Background

Intraoperative electron-beam radiation therapy (IOERT) during limb-sparing surgery has the advantage of delivering a single high boost dose to sarcoma residues and surgical bed area near to radiosensitive structures with limited toxicity. Retrospective studies have suggested that IOERT may improve local control compared to standard radiotherapy and we aimed to demonstrate this theory. Therefore, we performed an observational prospective study to determine (1) if it is possible to achieve high local control by adding IOERT to external-beam radiation therapy (EBRT) in extremity soft-tissue sarcomas (STS), (2) if it is possible to improve long-term survival rates, and (3) if toxicity could be reduced with IOERT

Materials and methods

From 1995−2003, 39 patients with extremity STS were treated with IOERT and postoperative radiotherapy. The median follow-up time was 13.2 years (0.7–19). Complications, locoregional control and survival rates were collected.

Results

Actuarial local control was attained in 32 of 39 patients (82%). Control was achieved in 88% of patients with primary disease and in 50% of those with recurrent tumors (p = 0.01). Local control was shown in 93% of patients with negative margins and in 50% of those with positive margins (p = 0.002). Limb-sparing was achieved in 32 patients (82%). The overall survival rate was 64%. 13% of patients had grade ≥3 acute toxicity, and 12% developed grade ≥3 chronic toxicity.

Conclusion

IOERT used as a boost to EBRT provides high local control and limb-sparing rates in patients with STS of the extremities, with less toxicity than EBRT alone.

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Authors and Affiliations

  1. Department of Traumatology and Orthopaedic Surgery, General Hospital Gregorio Marañón, Dr. Esquerdo, 46, 28007, Madrid, Spain

    Esther Carbó-Laso

  2. Hospital General Universitario Gregorio Marañón, Madrid, Spain

    Pablo Sanz-Ruiz, José Antonio Calvo-Haro, Miguel Cuervo-Dehesa, Rubén Pérez-Mañanes, Lydia Mediavilla-Santos, Coral Sánchez-Pérez, Ana Álvarez-González & Javier Vaquero-Martín

Authors
  1. Esther Carbó-Laso
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  2. Pablo Sanz-Ruiz
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  3. José Antonio Calvo-Haro
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  4. Miguel Cuervo-Dehesa
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  5. Rubén Pérez-Mañanes
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  6. Lydia Mediavilla-Santos
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  7. Coral Sánchez-Pérez
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  8. Ana Álvarez-González
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  9. Javier Vaquero-Martín
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Correspondence to Esther Carbó-Laso.

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The authors declare that they have no conflict of interest.

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No external funding was received for this study.

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Carbó-Laso, E., Sanz-Ruiz, P., Calvo-Haro, J.A. et al. Intraoperative radiotherapy for extremity soft-tissue sarcomas: can long-term local control be achieved? . Int J Clin Oncol 22, 1094–1102 (2017). https://doi.org/10.1007/s10147-017-1162-6

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  • DOI: https://doi.org/10.1007/s10147-017-1162-6

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