Abstract
Aims
Many epidemiological studies have investigated the correlation between adiponectin, C1Q and collagen domain containing (ADIPOQ) single nucleotide polymorphisms (SNPs) and risk of colorectal cancer (CRC). Although conflicting results have been reported, there was dispute regarding two SNPs (rs2241766 T/G and rs1501299 G/T). Therefore, we conducted a meta-analysis to systematically assess the associations and try to find the reasons for the dispute.
Methods
We searched PubMed, the Cochrane Library, Elsevier, Wiley Online Library, China National Knowledge Infrastructure, WanFang data and Chongqing VIP to search for all eligible case−control studies published up to January 2015. Effect sizes of odds ratios (OR) and 95 % confidence intervals (95 % CI) were calculated using a fixed- or random-effect model.
Results
Ten case–control studies including 4377 cases and 5584 controls were selected. A significant difference was observed in Chinese (OR 0.76; 95 % CI 0.68, 0.85; P < 0.001) and Ashkenazi Jewish populations (OR 0.79; 95 % CI 0.63, 0.99; P = 0.04) for rs2241766 with dominant model (TT vs TG + GG). A significant difference was observed in the Chinese population (OR 1.23; 95 % CI 1.11, 1.37; P < 0.001) for rs1501299 with dominant model (TT vs TG + GG). In addition, intake of red meat showed a synergistic effect between ADIPOQ gene and risk of colorectal cancer (CRC).
Conclusions
ADIPOQ SNPs rs2241766 T/G and rs 1501299 G/T have a population-specific correlation with risk of CRC. However, small sample studies may increase reporting bias, particularly if the total number of studies included in the analysis is small.
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References
Cnop M, Havel PJ, Utzschneider KM et al (2003) Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia 46:459–469
Gialamas SP, Petridou ET, Tseleni-Balafouta S et al (2011) Serum adiponectin levels and tissue expression of adiponectin receptors are associated with risk, stage, and grade of colorectal cancer. Metabolism 60:1530–1538
Ye C, Wang J, Tan S et al (2013) Meta-analysis of adiponectin polymorphisms and colorectal cancer risk. Int J Med Sci 10:1113–1120
Li Q, Ma Y, Sang W et al (2014) Five common haplotype-tagging variants of adiponectin (ADIPOQ) and cancer susceptibility: a meta-analysis. Genet Test Mol Biomarkers 18:417–424
Xu Y, He B, Pan Y et al (2013) The roles of ADIPOQ genetic variations in cancer risk: evidence from published studies. Mol Biol Rep 40:1135–1144
Ou Y, Chen P, Zhou Z et al (2014) Associations between variants on ADIPOQ and ADIPOR1 with colorectal cancer risk: a Chinese case-control study and updated meta-analysis. BMC Med Genet 15:137
Little J, Higgins JP, Ioannidis JP et al (2009) STrengthening the REporting of Genetic Association Studies (STREGA)–an extension of the STROBE statement. Genet Epidemiol 33:581–598
Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21:1539–1558
Higgins JP, Thompson SG, Deeks JJ et al (2003) Measuring inconsistency in meta-analyses. BMJ 27:557–560
DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188
Demets DL (1987) Methods for combining randomized clinical trials: strengths and limitations. Stat Med 6:341–350
Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50:1088–1101
Egger M, Smith GD, Phillips AN (1997) Meta-analysis: principles and procedures. BMJ 315:1533–1537
Moher D, Liberati A, Tetzlaff J et al (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 339:b2535
Al-Harithy RN, Al-Zahrani MH (2012) The adiponectin gene, ADIPOQ, and genetic susceptibility to colon cancer. Oncol Lett 3:176–180
Partida-Perez M, de la Luz Ayala-Madrigal M, Peregrina-Sandoval J et al (2010) Association of LEP and ADIPOQ common variants with colorectal cancer in Mexican patients. Cancer Biomark 7:117–121
Yi N, Kaklamani VG, Pasche B (2011) Bayesian analysis of genetic interactions in case-control studies, with application to adiponectin genes and colorectal cancer risk. Ann Hum Genet 75:90–104
Kaklamani VG, Wisinski KB, Sadim M et al (2009) Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk. JAMA 300:1523–1531
Al Khaldi RM, Al Mulla F, Al Awadhi S et al (2011) Associations of single nucleotide polymorphisms in the adiponectin gene with adiponectin levels and cardio-metabolic risk factors in patients with cancer. Dis Markers 30:197–212
Gornick MC, Rennert G, Moreno V, Gruber SB (2011) Adiponectin gene and risk of colorectal cancer. Br J Cancer 105:562–564
Pechlivanis S, Bermejo JL, Pardini B et al (2009) Genetic variation in adipokine genes and risk of colorectal cancer. Eur J Endocrinol 160:933–940
Keku TO, Vidal A, Oliver S et al (2012) Genetic variants in IGF-I, IGF-II, IGFBP-3, and adiponectin genes and colon cancer risk in African Americans and Whites. Cancer Causes Control 23:1127–1138
Tsilidis KK, Helzlsouer KJ, Smith MW et al (2009) Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer. Cancer Causes Control 20:1739–1751
Zhang Y, Feng QL, Liu CM et al (2012) Relationship between polymorphism sites of adiponection and its receptor gene and the susceptibility of colorectal cancer [Chinese Article]. Jiangsu Daxue Xuebao (Yixueban) 22:336–341
Guo X, Liu J, You L et al (2015) Association between adiponectin polymorphisms and the risk of colorectal cancer. Genet Test Mol Biomarkers 19:9–13
Hu X, Yuan P, Yan J et al (2013) Gene Polymorphisms of +45T > G, -866G > A, and Ala54Thr on the risk of colorectal cancer: a matched case-control study. PLoS One 8:e67275
Li X, Liu W, Feng F et al (2014) Association between adiponectin rs2241766, rs1501299 polymorphisms and the risk of colorectal cancer. Zhonghua Liu Xing Bing Xue Za Zhi 35:195–199
Li P, Liu H, Li C et al (2014) An updated meta-analysis of the association between ADIPOQ rs2241766 polymorphism and colorectal cancer. Tumour Biol 35:2491–2496
Gonzalez-Sanchez JL, Zabena CA, Martinez-Larrad MT et al (2005) An SNP in the adiponectin gene is associated with decreased serum adiponectin levels and risk for impaired glucose tolerance. Obes Res 13:807–812
Carvajal-Carmona LG, Spain S, Consortium C et al (2009) Common variation at the adiponectin locus is not associated with colorectal cancer risk in the UK. Hum Mol Genet 18:1889–1892
Oostindjer M, Alexander J, Amdam GV et al (2014) The role of red and processed meat in colorectal cancer development: a perspective. Meat Sci 97:583–596
Ochoa MC, Santos JL, Azcona C et al (2007) Association between obesity and insulin resistance with UCP2–UCP3 gene variants in Spanish children and adolescents. Mol Genet Metab 92:351–358
de Luis DA, Sagrado MG, Aller R et al (2009) Ala54Thr polymorphism of fatty acid binding protein 2, role on insulin resistance and cardiovascular risk factors in presurgical morbid obesity patients. Obes Surg 19:1691–1696
Yoon YS, Keum N, Zhang X et al (2015) Hyperinsulinemia, insulin resistance and colorectal adenomas: a meta-analysis. Metabolism 64:1324–1333
Melistas L, Mantzoros CS, Kontogianni M et al (2009) Association of the +45T > G and +276G > T polymorphisms in the adiponectin gene with insulin resistance in nondiabetic Greek women. Eur J Endocrinol 161:845–852
Acknowledgments
We thank the commercial support by the National Natural Science Foundation of China (81301691), the first Young Talents Foundation of Hubei Province (China, 2014) and Hubei Province Health and Family Planning scientific research project, WJ2015Z011. The Fundamental Research Funds for the Central Universities (HUST: 2015LC029).
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Ye, L., Wang, G., Tang, Y. et al. A population-specific correlation between ADIPOQ rs2241766 and rs 1501299 and colorectal cancer risk: a meta-analysis for debate . Int J Clin Oncol 22, 307–315 (2017). https://doi.org/10.1007/s10147-016-1044-3
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DOI: https://doi.org/10.1007/s10147-016-1044-3