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Clinical characteristics of Japanese lung cancer patients with human immunodeficiency virus infection

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Abstract

Background

Lung cancer has emerged as a crucial problem among human immunodeficiency virus (HIV)-infected patients, contributing to significant mortality in Western countries. Japan has an increasing number of newly infected HIV patients, but clinical characteristics of lung cancer have not been well investigated in Asian populations with HIV.

Patients and methods

We retrospectively analyzed patients diagnosed with HIV and lung cancer simultaneously in our institution between 1985 and 2010. Data regarding HIV status, characteristics, treatment, and prognosis of lung cancer were evaluated.

Results

We identified 13 consecutive patients (all men; mean age, 59.0 ± 10.2 years) since 1985, 7 of whom had been diagnosed since 2008. Mean CD4 cell count was 332 ± 159 cells/μL, and HIV viral loads were undetectable in 8 patients (61.5%) at the time of lung cancer diagnosis. The mean latency from HIV diagnosis to detection of lung cancer was 4.0 years. Histological examination demonstrated adenocarcinoma in 9 patients (69.2%), followed by squamous cell carcinoma (23.1%), and small cell carcinoma (7.7%). Among the 7 patients available for examination, 2 patients (28.6%) harbored EGFR mutation. Six patients had stage IA–IIIA, and 7 patients had stage IIIB/IV. Among 6 patients treated with chemotherapy for unresectable stages, 5 (83.3%) achieved a partial response. Median overall survival was 17 months for all stages and 14 months for advanced stages. Toxicities for treatment modalities were largely acceptable.

Conclusions

Clinical characteristics of Japanese HIV-infected patients with lung cancer resemble those of Western populations. The prognosis for patients in the metastatic stage was better than previously reported.

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Authors and Affiliations

  1. Department of Respiratory Medicine, Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital, 3-18-22 Honkomagome, Bunkyo, Tokyo, 113-8677, Japan

    Yusuke Okuma, Yusuke Takagi, Yukio Hosomi, Mari Iguchi, Tatsuru Okamura & Masahiko Shibuya

  2. Department of Infectious Diseases, Tokyo Metropolitan Cancer and Infectious diseases Center Komagome Hospital, 3-18-22 Honkomagome, Bunkyo, Tokyo, 113-8677, Japan

    Naoki Yanagisawa, Akihiko Suganuma, Akifumi Imamura & Atsushi Ajisawa

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  1. Yusuke Okuma
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  2. Naoki Yanagisawa
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  3. Yusuke Takagi
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  4. Yukio Hosomi
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  5. Akihiko Suganuma
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  6. Akifumi Imamura
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  7. Mari Iguchi
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  9. Atsushi Ajisawa
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  10. Masahiko Shibuya
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Correspondence to Yusuke Okuma.

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Okuma, Y., Yanagisawa, N., Takagi, Y. et al. Clinical characteristics of Japanese lung cancer patients with human immunodeficiency virus infection. Int J Clin Oncol 17, 462–469 (2012). https://doi.org/10.1007/s10147-011-0316-1

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  • DOI: https://doi.org/10.1007/s10147-011-0316-1

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