Abstract
In a 64-year-old man who had been treated with prednisolone (PSL) and 6-mercaptopurine (6MP) for a long period, for ulcerative colitis (UC), hepatocellular carcinoma (HCC) was detected incidentally. The UC was in remission with these medications. After he had been taking these medications for about 8 years, HCC was detected by computed tomography (CT), done for the evaluation of an other disease. Blood chemistry examination results were normal, except that the protein induced by vitamin K antagonist (PIVKA)-II level was 7940 AU/ml. We performed resection of liver segment V. With comparative genomic hybridization, chromosomal aberrations were recognized; these were gains of 1q, 3ptel-21, 8p12, and 22q11.23–22q13.1. Generally, HCC is associated with hepatitis virus infection in most cases, but in this patient, the HCC was not related to hepatitis C virus (HCV) or HBV. It is presumed that this case was related to the immunosuppressive therapy for UC and was associated with the gains of 1q, 3p, and 8p.
Similar content being viewed by others
References
A Kallioniemi OP Kallioniemi D Sudar et al. (1992) ArticleTitleComparative genomic hybridization for molecular cytogenetic analysis of solid tumors Science 258 818–821 Occurrence Handle1359641
K Nakao M Shibusawa A Ishihara et al. (2001) ArticleTitleGenetic changes in colorectal carcinoma tumors with liver metastases analyzed by comparative genomic hybridization and DNA ploidy Cancer 91 721–726 Occurrence Handle10.1002/1097-0142(20010215)91:4<721::AID-CNCR1057>3.0.CO;2-3 Occurrence Handle11241239
DH Present SJ Meltzer MP Krumholz et al. (1989) ArticleTitle6-Mercaptopurine in the management of inflammatory bowel disease: short- and long-term toxicity Ann Intern Med 111 641–649 Occurrence Handle2802419
BI Korelitz FJ Mirsky MR Fleisher et al. (1999) ArticleTitleMalignant neoplasms subsequent to treatment of inflammatory bowel disease with 6-mercaptopurine Am J Gastroenterol 94 3248–3253 Occurrence Handle10.1111/j.1572-0241.1999.01530.x Occurrence Handle10566724
AJ Lobo PN Foster DA Burke et al. (1990) ArticleTitleThe role of azathioprine in the management of ulcerative colitis Dis Colon Rectum 33 374–377 Occurrence Handle2328625
WR Connell MA Kamm M Dickson et al. (1994) ArticleTitleLong-term neoplasia risk after azathioprine treatment in inflammatory bowel disease Lancet 343 1249–1252 Occurrence Handle10.1016/S0140-6736(94)92150-4 Occurrence Handle7910274
DH Present (1993) ArticleTitleCyclosporine and other immunosuppressive agents: current and future role in the treatment of inflammatory bowel disease Am J Gastroenterol 88 627–630 Occurrence Handle8480721
S Russmann A Zimmermann S Krahenbuhl et al. (2001) ArticleTitleVeno-occlusive disease, nodular regenerative hyperplasia and hepatocellular carcinoma after azathioprine treatment in a patient with ulcerative colitis Eur J Gastroenterol Hepatol 13 287–290 Occurrence Handle10.1097/00042737-200103000-00013 Occurrence Handle11293451
FL Lee SM Murray J Prior et al. (1983) ArticleTitlePrimary liver cell cancer occurring in association with Crohn’s disease treated with prednisolone and azathioprine Hepatogastroenterology 30 188 Occurrence Handle6315555
S Cattan D Wendum O Chazouilleres et al. (2000) ArticleTitleHepatocellular carcinoma and focal hepatic glycogenosis after prolonged azathioprine therapy Hum Pathol 31 874–876 Occurrence Handle10.1053/hupa.2000.7629 Occurrence Handle10923928
S Euvrard C Ulrich N Lefrancois (2004) ArticleTitleImmunosuppressants and skin cancer in transplant patients: focus on rapamycin Dermatol Surg 30 628–633 Occurrence Handle10.1111/j.1524-4725.2004.30148.x Occurrence Handle15061847
R De Abreu L Lambooy E Stet et al. (1995) ArticleTitleThiopurine induced disturbance of DNA methylation in human malignant cells Adv Enzyme Regul 35 251–263 Occurrence Handle10.1016/0065-2571(94)00008-Q Occurrence Handle7572347
RB Nathanson PD Forbes F Urbach (1976) ArticleTitleModification of photocarcinogenesis by two immunosuppressive agents Cancer Lett 1 243–247 Occurrence Handle10.1016/S0304-3835(75)97305-X Occurrence Handle1016950
LJ Kinlen (1985) ArticleTitleIncidence of cancer in rheumatoid arthritis and other disorders after immunosuppressive treatment Am J Med 78 44–49 Occurrence Handle10.1016/0002-9343(85)90245-1
A Ishihara K Nakao H Yoshizawa et al. (1999) ArticleTitleComparative genomic hybridization analysis of chromosomal aberration associated with hepatitis C virus-related hepatocellular carcinoma Hepatol Res 15 32–42 Occurrence Handle10.1016/S1386-6346(99)00014-5
MA Collonge-Rame S Bresson-Hadni S Koch et al. (2001) ArticleTitlePattern of chromosomal imbalances in non-B virus related hepatocellular carcinoma detected by comparative genomic hybridization Cancer Genet Cytogenet 127 49–52 Occurrence Handle10.1016/S0165-4608(00)00421-0 Occurrence Handle11408065
A Marchio P Pineau M Meddeb et al. (2000) ArticleTitleDistinct chromosomal abnormality pattern in primary liver cancer of non-B, non-C patients Oncogene 19 3733–3738 Occurrence Handle10.1038/sj.onc.1203713 Occurrence Handle10949927
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Nakao, K., Tsunoda, A., Shimizu, Y. et al. Development of hepatocellular carcinoma following treatment with6-mercaptopurine for ulcerative colitis: investigation of chromosomal aberration by comparative genomic hybridization. Int J Clin Oncol 10, 281–284 (2005). https://doi.org/10.1007/s10147-005-0484-y
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s10147-005-0484-y