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Surgical treatment of carotid blowout syndrome after radiotherapy for head and neck malignant tumors: a single-center experience

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Abstract

To explore the treatments for and manifestations of carotid blowout syndrome (CBS) and to further explore the critical role of high-flow bypass combined with parent artery isolation. The clinical data of nine patients with radiotherapy-related CBS who were admitted to our hospital from March 2020 to March 2023 were retrospectively analyzed. Relevant literature was reviewed. From March 2020 to March 2023, nine CBS patients were admitted to Tianjin Huanhu Hospital, including eight males and one female. Digital subtraction angiography was performed for all the patients; all the pseudoaneurysms were located at the petrous segment of the internal carotid artery. A balloon occlusion test was performed on four patients, which was tolerated by all patients. CT and MRI scans showed seven cases of osteonecrosis combined with infection and two cases of tumor recurrence. Emergency permanent parent artery occlusion was performed on six patients, aneurysm embolization was completed in one case, covered stent implantation was performed in one patient, and three cases were treated by cerebral bypass surgery (including two patients with failed interventional treatment). Rebleeding was found in two patients, and no rebleeding was found in the bypass group. Paralysis was found in three patients, and asymptomatic cerebral infarction without permanent neurologic impairment was found in three patients. Two patients died due to tumor progression. Emergency occlusion surgery is lifesaving in the acute phase of CBS. Endovascular therapy cannot prevent the progression of pseudoaneurysms or lower the recurrence rate of bleeding events. High-flow bypass combined with parent artery isolation is a safe and effective method that may facilitate further surgical treatment. Further research is warranted.

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Acknowledgements

We express our sincere appreciation to Mrs. Zhirui Liu for the editorial assistance.

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Author notes

  1. Kaiming Gao and Wenqiang Guo contributed equally to this paper.

Authors and Affiliations

  1. Department of Neurosurgery, Tianjin Huanhu Hospital, 6 Jizhao Road, Jinnan District, Tianjin, 300350, China

    Kaiming Gao, Yanguo Shang, Minggang Shi & Xiaoguang Tong

  2. Department of Neurosurgery, Tianjin Central Hospital for Neurosurgery and Neurology, Tianjin, China

    Kaiming Gao, Yanguo Shang, Minggang Shi & Xiaoguang Tong

  3. Department of Neurosurgery, Qilu Hospital of Shandong University (Qingdao), 758 Hefei Road, Shibei District, Qingdao, Shandong, 266035, China

    Wenqiang Guo

  4. Department of Otorhinolaryngology, Tianjin Huanhu Hospital, Tianjin, China

    Gang Liu, Xiang Zhai & Haiyan Li

  5. Department of Otorhinolaryngology, Tianjin Central Hospital for Neurosurgery and Neurology, Tianjin, China

    Gang Liu, Xiang Zhai & Haiyan Li

  6. Laboratory of Microneurosurgery, Tianjin Neurosurgical Institute, Tianjin, China

    Xiaoguang Tong

  7. Tianjin Key Laboratory of Cerebral Vascular and Neural Degenerative Diseases, Tianjin, China

    Xiaoguang Tong

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  1. Kaiming Gao
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Contributions

XT raised and designed this subject. KG and WG collected and extracted data, and drafted the article. YS, GL, XZ, and HL collected and extracted data. MS commented the content. XT revised the manuscript and approved the version.

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Correspondence to Minggang Shi or Xiaoguang Tong.

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This study was approved by the Ethics Committee of the Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University.

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Gao, K., Guo, W., Shang, Y. et al. Surgical treatment of carotid blowout syndrome after radiotherapy for head and neck malignant tumors: a single-center experience. Neurosurg Rev 46, 293 (2023). https://doi.org/10.1007/s10143-023-02193-z

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