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Clinical features and long-term outcomes of pediatric intraventricular meningiomas: data from a single neurosurgical center

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Abstract

The purpose of this study is to investigate the clinical characteristics and long-term outcomes of pediatric patients with intraventricular meningioma. We retrospectively analyzed a total of 30 pediatric patients with intraventricular meningiomas who were surgically treated at our department between January 2005 and June 2016 and analyzed their clinical characteristics and surgical outcomes. Among the 160 pediatric patients with intracranial meningioma, 33 (20.6%) had intraventricular lesions. However, only 30 patients had complete demographic and clinical data. A male predilection (male/female = 1.5:1) was observed, and the mean age of our patient cohort was 12.6 years. The lateral ventricle was the most common lesion site (88.6%). In addition, the most common initial symptom was headache or dizziness, and the average interval from symptom onset to admission was 19.17 months (0.25–72 months). Twenty-six patients (86.7%) achieved a Simpson grade of I. Based on the WHO classification, 28 (93.3%) meningiomas were classified as grade I, and the remaining two cases were grades II and III. During the follow-up period (0.67–10.08 years), 3 patients experienced tumor recurrence (15, 18, and 83 months, respectively), and 1 patient died of recurrence. Pediatric and adult intraventricular meningiomas present similar clinical characteristics and surgical outcomes; however, intraventricular meningiomas compose a higher percentage of pediatric meningiomas and have a male predilection. Compared with general pediatric meningiomas, pediatric intraventricular meningiomas tend to have higher incidence of benign subtypes. They are also more likely to be completely resected and have lower recurrence and mortality rates.

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References

  1. Arivazhagan A, Devi BI, Kolluri SV, Abraham RG, Sampath S, Chandramouli BA (2008) Pediatric intracranial meningiomas—do they differ from their counterparts in adults? Pediatr Neurosurg 44:43–48. doi:10.1159/000110661

    Article  CAS  PubMed  Google Scholar 

  2. Baumgartner JE, Sorenson JM (1996) Meningioma in the pediatric population. J Neuro-Oncol 29:223–228

    Article  CAS  Google Scholar 

  3. Caroli E, Russillo M, Ferrante L (2006) Intracranial meningiomas in children: report of 27 new cases and critical analysis of 440 cases reported in the literature. J Child Neurol 21:31–36

    Article  PubMed  Google Scholar 

  4. Danaila L (2013) Primary tumors of the lateral ventricles of the brain. Chirurg 108:616–630

    CAS  Google Scholar 

  5. Deen HG Jr, Scheithauer BW, Ebersold MJ (1982) Clinical and pathological study of meningiomas of the first two decades of life. J Neurosurg 56:317–322. doi:10.3171/jns.1982.56.3.0317

    Article  PubMed  Google Scholar 

  6. Elbabaa SK, Gokden M, Crawford JR, Kesari S, Saad AG (2012) Radiation-associated meningiomas in children: clinical, pathological, and cytogenetic characteristics with a critical review of the literature. J Neurosurg Pediatr 10:281–290. doi:10.3171/2012.7.PEDS1251

    Article  PubMed  Google Scholar 

  7. Fornari M, Savoiardo M, Morello G, Solero CL (1981) Meningiomas of the lateral ventricles. Neuroradiological and surgical considerations in 18 cases. J Neurosurg 54:64–74. doi:10.3171/jns.1981.54.1.0064

    Article  CAS  PubMed  Google Scholar 

  8. Kawahara Y, Nakada M, Hayashi Y, Kai Y, Hayashi Y, Uchiyama N, Nakamura H, Kuratsu J, Hamada J (2012) Prediction of high-grade meningioma by preoperative MRI assessment. J Neuro-Oncol 108:147–152. doi:10.1007/s11060-012-0809-4

    Article  Google Scholar 

  9. Kim EY, Kim ST, Kim HJ, Jeon P, Kim KH, Byun HS (2009) Intraventricular meningiomas: radiological findings and clinical features in 12 patients. Clin Imaging 33:175–180. doi:10.1016/j.clinimag.2008.09.005

    Article  PubMed  Google Scholar 

  10. Kobata H, Kondo A, Iwasaki K, Kusaka H, Ito H, Sawada S (1998) Chordoid meningioma in a child. Case report. J Neurosurg 88:319–323. doi:10.3171/jns.1998.88.2.0319

    Article  CAS  PubMed  Google Scholar 

  11. Kotecha RS, Junckerstorff RC, Lee S, Cole CH, Gottardo NG (2011) Pediatric meningioma: current approaches and future direction. J Neuro-Oncol 104:1–10. doi:10.1007/s11060-010-0503-3

    Article  Google Scholar 

  12. Kotecha RS, Pascoe EM, Rushing EJ, Rorke-Adams LB, Zwerdling T, Gao X, Li X, Greene S, Amirjamshidi A, Kim SK, Lima MA, Hung PC, Lakhdar F, Mehta N, Liu Y, Devi BI, Sudhir BJ, Lund-Johansen M, Gjerris F, Cole CH, Gottardo NG (2011) Meningiomas in children and adolescents: a meta-analysis of individual patient data. Lancet Oncol 12:1229–1239. doi:10.1016/S1470-2045(11)70275-3

    Article  PubMed  Google Scholar 

  13. Li H, Zhao M, Wang S, Cao Y, Zhao J (2016) Prediction of pediatric meningioma recurrence by preoperative MRI assessment. Neurosurg Rev 39:663–669. doi:10.1007/s10143-016-0716-9

    Article  PubMed  Google Scholar 

  14. Li P, Diao X, Bi Z, Hao S, Ren X, Zhang J, Xing J (2015) Third ventricular meningiomas. J Clin Neurosci: Off J Neurosurg Soc Aust 22:1776–1784. doi:10.1016/j.jocn.2015.05.025

    Article  Google Scholar 

  15. Li Z, Li H, Jiao Y, Ma J, Wang S, Zhao J, Cao Y (2016) A comparison of clinicopathological features and surgical outcomes between pediatric skull base and non-skull base meningiomas. Child's Nerv Syst: ChNS: Off J Int Soc Pediatr Neurosurg. doi:10.1007/s00381-016-3278-9

  16. Li Z, Li H, Wang S, Zhao J, Cao Y (2016) Pediatric skull base meningiomas: clinical features and surgical outcomes. J Child Neurol 31:1523–1527. doi:10.1177/0883073816664669

    Article  PubMed  Google Scholar 

  17. Lin BJ, Chou KN, Kao HW, Lin C, Tsai WC, Feng SW, Lee MS, Hueng DY (2014) Correlation between magnetic resonance imaging grading and pathological grading in meningioma. J Neurosurg 121:1201–1208. doi:10.3171/2014.7.JNS132359

    Article  PubMed  Google Scholar 

  18. Liu M, Wei Y, Liu Y, Zhu S, Li X (2006) Intraventricular meninigiomas: a report of 25 cases. Neurosurg Rev 29:36–40. doi:10.1007/s10143-005-0418-1

    Article  CAS  PubMed  Google Scholar 

  19. Ma J, Cheng L, Wang G, Lin S (2014) Surgical management of meningioma of the trigone area of the lateral ventricle. World Neurosurg 82:757–769. doi:10.1016/j.wneu.2014.05.026

    Article  PubMed  Google Scholar 

  20. Majos C, Cucurella G, Aguilera C, Coll S, Pons LC (1999) Intraventricular meningiomas: MR imaging and MR spectroscopic findings in two cases. AJNR Am J Neuroradiol 20:882–885

    CAS  PubMed  Google Scholar 

  21. Mehta N, Bhagwati S, Parulekar G (2009) Meningiomas in children: a study of 18 cases. J Pediatr Neurosci 4:61–65. doi:10.4103/1817-1745.57322

    Article  PubMed  PubMed Central  Google Scholar 

  22. Nakamura M, Roser F, Bundschuh O, Vorkapic P, Samii M (2003) Intraventricular meningiomas: a review of 16 cases with reference to the literature. Surg Neurol 59:491–503 discussion 503-494

    Article  PubMed  Google Scholar 

  23. Odegaard KM, Helseth E, Meling TR (2013) Intraventricular meningiomas: a consecutive series of 22 patients and literature review. Neurosurg Rev 36:57–64; discussion 64. doi:10.1007/s10143-012-0410-5

    Article  PubMed  Google Scholar 

  24. Perry RD, Parker GD, Hallinan JM (1990) CT and MR imaging of fourth ventricular meningiomas. J Comput Assist Tomogr 14:276–280

    Article  CAS  PubMed  Google Scholar 

  25. Rushing EJ, Olsen C, Mena H, Rueda ME, Lee YS, Keating RF, Packer RJ, Santi M (2005) Central nervous system meningiomas in the first two decades of life: a clinicopathological analysis of 87 patients. J Neurosurg 103:489–495. doi:10.3171/ped.2005.103.6.0489

    PubMed  Google Scholar 

  26. Wang XQ, Jiang CC, Zhao L, Gong Y, Hu J, Chen H (2012) Clinical features and treatment of World Health Organization grade II and III meningiomas in childhood: report of 23 cases. J Neurosurg Pediatr 10:423–433. doi:10.3171/2012.7.PEDS12179

    Article  PubMed  Google Scholar 

  27. Whittle IR, Smith C, Navoo P, Collie D (2004) Meningiomas. Lancet 363:1535–1543. doi:10.1016/S0140-6736(04)16153-9

    Article  PubMed  Google Scholar 

  28. Zhang BY, Yin B, Li YX, Wu JS, Chen H, Wang XQ, Geng DY (2012) Neuroradiological findings and clinical features of fourth-ventricular meningioma: a study of 10 cases. Clin Radiol 67:455–460. doi:10.1016/j.crad.2011.10.017

    Article  PubMed  Google Scholar 

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Acknowledgments

We wound thank Dr. Meng Zhao for his assistance in the data collection.

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Author notes

  1. Zhicen Li and Hao Li contributed equally to this study.

Authors and Affiliations

  1. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No.6 Tiantanxili, Beijing, 100050, China

    Zhicen Li, Hao Li, Yuming Jiao, Ji Ma, Shuo Wang, Yong Cao & Jizong Zhao

  2. China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China

    Zhicen Li, Hao Li, Yuming Jiao, Ji Ma, Shuo Wang, Yong Cao & Jizong Zhao

Authors
  1. Zhicen Li
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  2. Hao Li
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  3. Yuming Jiao
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  4. Ji Ma
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  5. Shuo Wang
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  6. Yong Cao
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  7. Jizong Zhao
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Correspondence to Yong Cao.

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The authors declare that they have no conflict of interest.

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This research with approved by the research ethics committee of the Beijing Tiantan Hospital, Capital Medical University, Beijing.

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Informed consent was obtained from all individual participants included in the study.

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Li, Z., Li, H., Jiao, Y. et al. Clinical features and long-term outcomes of pediatric intraventricular meningiomas: data from a single neurosurgical center. Neurosurg Rev 41, 525–530 (2018). https://doi.org/10.1007/s10143-017-0884-2

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  • DOI: https://doi.org/10.1007/s10143-017-0884-2

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