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Inhibitory Effects of Mediterranean Sponge Extracts and Metabolites on Larval Settlement of the Barnacle Balanus amphitrite

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Abstract

One of the most promising alternative technologies to antifouling paints based on heavy metals is the development of coatings whose active ingredients are compounds naturally occurring in marine organisms. This approach is based on the problem of epibiosis faced by all marine organisms and the fact that a great number of them cope with it successfully. The present study investigated the antifouling activity of a series of extracts and secondary metabolites from the epibiont-free Mediterranean sponges Ircinia oros, I. spinosula, Cacospongia scalaris, Dysidea sp., and Hippospongia communis. Antifouling efficacy was evaluated by the settlement inhibition of laboratory-reared Balanus amphitrite Darwin cyprids. The most promising activity was exhibited by the metabolites 2-[24-acetoxy]-octaprenyl-1-4-hydroquinone (8a), dihydrofurospongin II (10), and the alcoholic extract of Dysidea sp.

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Acknowledgments

We thank the National Fellowship Foundation for provision of a fellowship to one of us (M.T.), and the General Secretariat for Research and Technology and the University of Athens for financial support of the Greek research team. The British team was supported by an award from the U.S. Office of Naval Research (N00014-02-1-0311). We also thank Dr. Dan Rittschof, Dr. Nikos Mihopoulos, Mr. Dennis Abatis, Mr. Lefteris Marinos, and Mrs. Sheelagh Henry for their assistance on different aspects of the present investigation.

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Authors and Affiliations

  1. Newcastle University, School of Marine Science and Technology, Newcastle upon Tyne, NE1 7RU, U.K.

    Claire Hellio, Jean-Philippe Maréchal, Nick Aldred & Anthony S. Clare

  2. Division of Pharmacognosy and Chemistry of Natural Products, University of Athens, School of Pharmacy, Panepistimiopolis Zografou, Athens, 157 71, Greece

    Maria Tsoukatou, Constantinos Vagias & Vassilios Roussis

  3. Station Marine du Muséum National d’Histoire Naturelle, USM 405, BP 225, Concarneau Cedex, 29182, France

    Claude Beaupoil

  4. Present address: Laboratorie MFS, Faculté des Sciences et Techniques, Université du Sud-Toulon Var, BP 20132, 83957 La Garde Cedex, France

    Claire Hellio

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  1. Claire Hellio
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  2. Maria Tsoukatou
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  3. Jean-Philippe Maréchal
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  8. Vassilios Roussis
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Correspondence to Vassilios Roussis.

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Hellio, C., Tsoukatou, M., Maréchal, JP. et al. Inhibitory Effects of Mediterranean Sponge Extracts and Metabolites on Larval Settlement of the Barnacle Balanus amphitrite. Mar Biotechnol 7, 297–305 (2005). https://doi.org/10.1007/s10126-004-3150-x

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